Relations between serum and pleural fluid biomarkers: a new look of an old concept

The Egyptian Journal of Bronchology

Table 5 Sensitivity, specificity, PPV, and NPV of cancer ratio and age at different cutoff points

	Cutoff points	Sensitivity (%)	95% CI	Specificity (%)	95% CI	LR+	LR−	PPV(%)	NPV(%)
Age	> 39.5	100	0.9615 to 1.000	45	0.3134 to 0.5853	1.81	0.00	28	100
	> 49	90	0.8260 to 0.9553	64	0.5036 to 0.7664	2.53	0.15	36	97
	> 60.5	40	0.3042 to 0.5105	93	0.8271 to 0.9802	5.66	0.64	55	88
	> 70.5	12	0.05989 to 0.1997	98	0.9045 to 0.9995	6.54	0.90	59	84
Cancer ratio	>5.61	100	0.9615 to 1.000	27	0.1583 to 0.4030	1.37	0.00	23	100
	> 7.93	90	0.8260 to 0.9553	54	0.3974 to 0.6701	1.95	0.18	30	96
	> 9.89	82	0.7263 to 0.8910	75	0.6163 to 0.8561	3.28	0.24	42	95
	> 13.39	70	0.5990 to 0.7921	93	0.8271 to 0.9802	9.83	0.32	68	93
	> 16.02	61	0.5002 to 0.7056	96	0.8769 to 0.9956	16.99	0.41	79	92
	> 18.26	47	0.3644 to 0.5739	100	0.9362 to 1.000		0.53	100	90

LR+ positive likelihood ratio, LR− negative likelihood ratio, PPV positive predictive value, NPV negative predictive value, CI confidence interval