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Table 2 The performance criteria of the laboratory markers in discriminating the severity of COVID-19

From: Interleukin-6 and C-reactive protein/albumin ratio as predictors of COVID-19 severity and mortality

Parameters

Cutoff

Youden’s index

AUC (95% CI)

Sensitivity

Specificity

PPV

NPP

Accuracy

IL-6, pg/mL

> 32.3

0.77

0.955 (0.912-0.997)

82.4%

94.4%

73.7%

96.9%

93.1%

CRP/albumin ratio

> 8.9

0.73

0.922 (0.862-0.981)

82.4%

90.9%

60.9%

96.8%

89.7%

CRP, mg/L

> 33.9

0.65

0.889 (0.805-0.973)

76.5%

88.9%

54.2%

95.7%

87.1%

Albumin, g/dL

< 3.8

0.42

0.672 (0.537-0.806)

82.4%

60.6%

26.4%

95.2%

63.8%

  1. AUC area under the ROC; CI confidence interval; CRP C-reactive protein; IL-6 interleukin 6