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The Egyptian Journal of Bronchology
Fig. 2 | The Egyptian Journal of Bronchology

Fig. 2

From: Dynamic role of LMW-hyaluronan fragments and Toll-like receptors 2,4 in progression of bleomycin induced lung parenchymal injury to fibrosis

Fig. 2

a Macrophage infiltration in lung parenchyma before and after bleomycin instillation. Weak CD68 positive macrophages were seen in saline control lungs and on day 0 bleomycin (a, b) by immunohistochemistry. c Note the increase in CD68 expression and influx of macrophages on day 7 after bleomycin instillation (c) that persists up to days 14 and 28 (d, e). f Quantification of CD68 protein expression by macrophages shows significant increase in CD68 protein intensity from day 7 onwards up to day 28. ***p < 0.0001 group II B, group II C, group II D vs. group II A, group I. g A significant net influx of macrophages/high power field (× 400) is seen after bleomycin instillation by morphometry on day 14 that persisted up to day 28. ***p < 0.0001 group II C, group II D vs. group II A, group I; ^^^p < 0.0001 group II C, group II D vs. group II B

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