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The Egyptian Journal of Bronchology
Fig. 4 | The Egyptian Journal of Bronchology

Fig. 4

From: Dynamic role of LMW-hyaluronan fragments and Toll-like receptors 2,4 in progression of bleomycin induced lung parenchymal injury to fibrosis

Fig. 4

Toll like receptor-4 (TLR-4) mRNA and protein expression in lungs before and after bleomycin instillation. As compared to saline control and bleomycin day 0 (a, b), on day 7 and 14 after bleomycin instillation, an increased TLR-4 expression is seen in AECs, bronchiolar epithelial cells, and alveolar and interstitial macrophages, on day 7 and on day 14 after bleomycin instillation (c, d respectively). e On day 28, TLR-4 protein expression persists in AECs, bronchiolar epithelial cells, and alveolar and interstitial macrophages. f Quantification of the intensity of TLR-4 protein expression in the lung parenchyma. Significant increase in TLR-4 expression was seen from day 7 onwards that persisted up to day 28. ***p < 0.0001 group II B, group II C and group II D vs. group II A and group I. g TLR-4 mRNA levels were upregulated on day 7 and returned to baseline on day 14 and day 28. **p < 0.001 group II B vs. group II A; ^^^p < 0.0001 group II B vs. group II D and group I

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