Table 1 Major SARS-CoV-2 Variants in circulation
WHO label | Pango Lineage (VOC/VOI/VUI) | GISAID Clade | Originating country | First detectionL452R, E484Q, P681R | Significant mutations |
|---|---|---|---|---|---|
Alpha | B.1.1.7 (VOC) | GRY | Kent, UK | In November 2020 (Sample from September 2020) | N501Y (mutation in RBD), 69-70del (Spontaneous Spike mutation), P681H (mutation near S1/S2 furin cleavage site), |
Beta | B.1.351 B.1.351.2 B.1.351.3 (VOC) | GH/501Y.V2 | South Africa | Nelson Mandela Bay, South Africa in May 2020 | N501Y, K417N, E484K (Mutation in RBD of spike protein) |
Gamma | P.1 P.1.1 P.1.2 (VOC) | GR/501Y.V3 | Brazil | Brazil in November 2020 | N501Y, K417T, E484K (Spike protein mutations) |
Delta | B.1.617.2 AY.1 AY.2 AY.3 (VOC) | G/478K.V1 | India | Maharashtra, India on 5 October 2020 | E484Q, L452R, P681R (Spike protein mutations) |
Eta | B.1.525 (VOI) | G/484K.V3 | Nigeria, UK | December 2020 in UK and Nigeria in December 2020 | E484K, F888L (Mutation in S2 domain of spike protein), 69-70del (Spontaneous Spike mutation), |
Iota | B.1.526 (VOI) | GH/253G.V1 | USA | New York, the USA in November 2020 | T95I, E484K, D253G, D614G (Spike protein mutations) |
Kappa | B.1.617.1 | G/452R.V3 | India | October 2020 | L452R, E484Q, P681R |
Lambda | C.37 (VOI) | GR/452Q.V1 | Peru | December 2020 | G75V, T76I, Δ246-252, L452Q, F490S, D614G, T859N |