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Table 2 Univariate Cox analysis of the risk factors for the severity of COVID-19

From: Predictors of severity and mortality in COVID-19 patients

Variable

Moderate (n = 108)

Severe/critical (n = 67)

P

Demographic character

 Agea

58 ± 14

60.3 ± 14.3

0.3ƪ

 Sex

  Femalea

26 (24%)

13 (19.4%)

0.46$

  Malea

82 (75.9%)

54 (80.6%)

 

 Comorbiditya

47 (43.5%)

49 (73.1%)

< 0.001$

  DMa

32 (32.6%)

31 (46.3%)

0.02$

  HTNa

31 (28.7%)

32 (47.8%)

0.01$

  IHDa

3 (2.8%)

5 (7.5%)

0.15$

  Malignancya

3 (2.8%)

4 (5.9%)

0.31$

  Renala

3 (2.8%)

10 (14.9%)

0.001$

Admission labs

 TLC (× 103/μl)b

9.55 (6.7–12.5)

15.00 (10–18.8)

< 0.001§

 Lymphocyte (/μl)b

1611 (1259–2168)

1281 (846–2255)

< 0.001§

 HB (g/dl)c

13.32 ± 1.88

12.97 ± 2

0.12ƪ

 PLT (× 103/μl)b

299 (230–376)

304 (217–414)

0.76§

 AST (U/l)b

39 (25–52)

57 (38–85)

< 0.001§

 ALT (U/l)b

46 (29–77)

65 (43–106)

< 0.001§

 Urea (mg/dl)b

47 (36–72.5)

66 (49–167)

< 0.001§

 Creatine (mg/dl)b

1 (0.8–1.2)

1.1 (0.9–1.9)

0.11§

 d-dimer (μg/ml)b

680 (427–1398)

2216.64 (908–6830)

< 0.001§

 Ferritin (ng/dl)b

794 (376–1415)

2198 (890–2645)

< 0.001§

 CRP (mg/l)b

74.60 (31.7–126)

173.8 (80.4–263.3)

< 0.001§

  1. DM Diabetes mellitus, HTN Hypertension, IHD Ischemic heart disease, TLC Total leukocytic count, Hb Hemoglobin, PLT Platelets, AST Aspartate aminotransferase, ALT Alanine transaminase, CRP C-reactive protein
  2. ƪIndependent t-test
  3. §Mann-Whitney test
  4. $Chi-square test, P < 0.05 considered significant
  5. aData are represented as number and percentage
  6. bData are represented as median and interquartile range
  7. cData are represented as mean and standard deviation