Table 2 Univariate analysis between the different types of pleural effusion
From: Relations between serum and pleural fluid biomarkers: a new look of an old concept
Variable | Malignant (n = 94) | Tuberculous (n = 31) | Para-pneumonic (n = 25) | P1 | P2 | P3 |
|---|---|---|---|---|---|---|
Age | 59.97 (9.25) | 38.03 (10.8) | 49.16 (13.18) | < 0.001 | < 0.001 | < 0.001 |
Pleural fluid glucose | 90 (75–109.25) | 87 (60–100) | 70 (52.5–90.5) | 0.5 | 0.01 | 0.1 |
Pleural fluid protein | 4.67 (0.9) | 4.84 (1.2) | 4.96 (0.9) | 0.41* | ||
Serum protein | 6.45 (5.9–7) | 6.5 (5.8–7.1) | 6.5 (5.8–7) | 0.99* | ||
Pleural fluid/serum protein | 0.71 (0.61–0.82) | 0.77 (0.64–0.9) | 0.76 (0.61–0.88) | 0.34* | ||
Pleural fluid LDH | 555 (355.75–1011) | 600 (299–844) | 469 (321–1046) | 0.89* | ||
Serum LDH | 342.5 (233.75–420) | 220 (189–276) | 220 (190–259) | 0.001 | 0.001 | 0.9 |
Pleural fluid LDH/Serum LDH | 1.75 (1.07–3.34) | 2.59 (1.49–3.63) | 2.13 (1.25–4.95) | 0.06 | ||
Pleural fluid ADA | 19 (11–25) | 38 (29–42) | 24 (20–30) | < 0.001 | 0.001 | < 0.001 |
Cancer ratio | 18.03 (10.87–29.73) | 6.1 (4.64–9.17) | 8.7 (6.79–11.79) | < 0.001 | < 0.001 | < 0.001 |
Pleural fluid lymphocyte count | 0.5 (0.4–0.6) | 0.88 (0.8–0.95) | 0.2 (0.15–0.3) | < 0.001 | < 0.001 | < 0.001 |
Cancer ratio plus | 40.13 (24.68–60.88) | 8.06 (5.22–11.14) | 47.5 (32.15–68.78) | < 0.001 | 0.5 | < 0.001 |
Serum LDH/pleural fluid lymphocyte count | 700 (506.8–950.4) | 271.11 (216.49–332.5) | 1200 (762.12–1754.54) | < 0.001 | < 0.001 | < 0.001 |