Effect of acute kidney injury on weaning from mechanical ventilation in chronic obstructive pulmonary diseases patients with respiratory failure

The Egyptian Journal of Bronchology

Table 5 Relation between kidney injury and APACHE II score, MV parameters, duration of ICU stay, and GFR among the studied groups

Variable		Non-AKI (no. = 42) Mean ± SD	AKI (no. = 58) Mean ± SD	Test	P
APACHE II score		17.19 ± 4.79	21.65 ± 6.77	Z = 2	0.04
Mechanical ventilation parameters	PEEP	5 ± 0	5.96 ± 1.88	Z = 2.39	0.02(S)
	Vt ml/kg	7.05 ± 0.74	7.03 ± 0.73	Z = 0.05	0.9
	RR	12 ± 0	12.38 ± 0.73	Z = 1.4	0.15
	PaO₂/FiO₂	236.3 ± 33.73	233.9 ± 23.05	Z = 0.69	0.49
	Inspiratory pressure	10.97 ± 1.88	11.05 ± 1.6	Z = − 0.59	0.56
Time of stay in ICU in days		8.38 ± 1.36	12.03 ± 6.01	Z = 3.04	0.002(S)
Time of mechanical ventilation in days		5.38 ± 1.16	9.14 ± 5.15	Z = 3.90	< 0.001(HS)
Time of starting MV in days		1.71 ± 0.56	1.9 ± 0.82	t = 0.88	0.38
GFR after 48 h of admission (ml/min/1.73 m²)		105.09 ± 11.36	41.69 ± 5.75	t = 25.88	< 0.001(HS)

APACHE II acute physiology and chronic health evaluation II, AKI acute kidney injury, MV mechanical ventilation, GFR glomerular fiteration rate, Vt tidal volume, RR respiratory rate, PaO₂/FiO₂ arterial oxygen tension/fraction of inspired oxygen, ICU intensive care unit, AKI acute kidney injury, PEEP positive end-expiratory pressure