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The Egyptian Journal of Bronchology
Fig. 3 | The Egyptian Journal of Bronchology

Fig. 3

From: Dynamic role of LMW-hyaluronan fragments and Toll-like receptors 2,4 in progression of bleomycin induced lung parenchymal injury to fibrosis

Fig. 3

Toll-like receptor-2 (TLR-2) mRNA and protein expression in lungs before and after bleomycin instillation: As compared to saline control and bleomycin day 0 (a, b), on day 7 and 14 after bleomycin instillation, an increased TLR-2 expression is seen in AECs, perivascular inflammatory cells, alveolar and interstitial macrophage by immunohistochemistry (c, d respectively). e On day 28, in fibrotic phase, TLR-2 protein expression persisted in AECs, alveolar and interstitial macrophages of lung parenchyma. f Quantification of the intensity of TLR-2 protein expression in the lung parenchyma. Significant increase in TLR-2 protein expression was seen from day 7 that persisted up to day 28. ***p < 0.0001 group II B, group II C, group II D vs. group II A and group I. g TLR-2 mRNA levels were significantly upregulated on day 7 and day 14 and returned to baseline on day 28. **p < 0.001 group II B vs. group II A; ***p < 0.0001 group II C vs. group II A

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