Table 1 A summary of the sensitivity, specificity, PPV, NPV, and d-dimer cutoffs considering the CTPA as the standard
Authors | Number of the studied population | Sensitivity | Specificity | Positive predictive value | Negative predictive value | d-dimer cutoff (mg/L) |
|---|---|---|---|---|---|---|
Cui et al. [80] | 81 | 85% | 88.5% | 70.8% | 94.7% | 1.5 |
Delemo-Rodriguez et al. [79] | 156 | 95.7% | 29.3% | 19% | 97.5% | 1.570 |
Leonard-Lorant et al. [83] | 160 | 100% | 67% | N/A | N/A | 2.660 |
Maatman et al. [84] | 109 | 89.7% | 59.5% | N/A | N/A | 2.600 |
Ventrua-diaz et al. [76] | 242 | 81% | 59% | N/A | N/A | 2.903 |
90% | 51.4% | N/A | N/A | 1.733 | ||
Tuck et al. [85] | 544 | 81% | 71% | N/A | N/A | 1.500 |
80% | 76% | N/A | N/A | 2.00 | ||
Bledsoe et al. [86] | 3583 | 70.3% | 82.4% | N/A | 98.5% | 2.00 |
99.3% | 34.3% | N/A | 99.9% | 0.5 | ||
13,091 | 70.5% | 67.8% | N/A | 99.5% | 2.00 | |
92% | 17.0% | N/A | 99.5% | 0.5 | ||
Revel et al. [87] | 781 | 98.3% | 10.8% | 8.4% | 98.7% | 0.5 |
90.0% | 41.6% | 11.4% | 98.0% | 1.00 | ||
80% | 73.8% | 20.3% | 97.8% | 2.00 | ||
66.7% | 83.6% | 23.3% | 97.1% | 3.00 | ||
Nadeem et al. [88] | 193 | 100% | 90.62% | 68.75% | 100% | 2.494 |
Ooi et al. [22] | 974 | 72% | 74% | N/A | N/A | 2.247 |
Alonso-Fernandez et al. [89] | 30 | 100% | 0% | 50% | 0% | 1.00 |
93% | 13% | 52% | 67% | 1.50 | ||
87% | 40% | 59% | 75% | 2.00 | ||
80% | 53% | 63% | 73% | 2.50 | ||
Vivan et al. [81] | 697 | 98.2% | 5.7% | 33.3% | 87.1% | 0.5 |
Ramadan et al. [72] | 139 | 78% | 67% | N/A | N/A | 2.00 |
Planquette et al. [90] | 59 | 100% | 9.0% | 6.2% | 100% | 0.5 |
76.1% | 65.0% | 11.6% | 97.8% | 1.50 | ||
50% | 84% | 15.9% | 96.5% | 2.50 | ||
43.5% | 90% | 20.3% | 96.4% | 3.50 | ||
Loffi et al. [91] | 333 | 70% | 62% | N/A | N/A | 2.37 |
Mouhat et al. [92] | 349 | 83.3% | 83.8% | 72.9% | 90.5% | 2.590 |
Taccone et al. [93] | 40 | 75% | 92% | N/A | N/A | 3.647 |
Whyte et al. [94] | 1477 | 75% | 78% | 72.2% | 80.9% | 4.8 |