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The Egyptian Journal of Bronchology
Fig. 2 | The Egyptian Journal of Bronchology

Fig. 2

From: Diagnostic yield of combined ultrasound-guided fine needle aspiration and core needle biopsy versus either technique alone in peripheral lung and pleural lesions

Fig. 2

Pathologic diagnosis of three different patients. A, B A case of pleural tuberculosis. A CNB showing multiple granulomas (arrow) with Langhans giant cell (dashed arrow) (H&E, ×100). B FNAB showing necrotic background (arrowhead) incorporating few macrophages and mixed inflammatory cells (failed to diagnose the case). C, D A case of lung adenocarcinoma. C CNB showing multiple large glands lined by atypical cells (arrows) (H&E, ×200). Insets show positive TTF-1 nuclear stain and score 3 EGFR membranous stain. D FNAB showing clusters of malignant cells with vague attempts of acinar formation (arrow heads). Insets show positive TTF-1 and score 3 EGFR (concordant with CNB). E, F A case of squamous cell carcinoma. E CNB showing nest of cohesive malignant cells with ample eosinophilic cytoplasm (arrows). (H&E, ×100) Insets show positive P63 nuclear stain and negative TTF-1 confirming diagnosis of SCC. F FNAB shows sheets of atypical cells with eosinophilic cytoplasm (arrow heads). Insets reveal positive P63 and negative TTF-1 (concordant with CNB). (H&E, ×100). Insets (IHC, ×100). CNB core needle biopsy, FNAB fine needle biopsy, TTF-1 thyroid transcription factor-1, EGFR epidermal growth factor receptor, SCC squamous cell carcinoma

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