Table 1 Specifications of the articles that were reviewed
Authors (year) | Number of samples/animal | Age/weight | Prescription type | Material for creating the ALI model | Effects of quercetin | Results | |
|---|---|---|---|---|---|---|---|
1 | Şengül (2017) [27] | 50/Rat | Adult/250 | Intraperitoneal | Cyclophosphamide | It prevented tissue damage and increased density of mast cells in lung tissue | Quercetin provides a lung protective effect by inhibiting ROS and mast cell degranulation |
2 | Farazuddin (2018) [23] | 36/Mice | 8 weeks/N | Intranasal | Rhinovirus | Quercetin attenuated all pathological changes in mice with COPD phenotype induced by rhinovirus | Quercetin may be useful in treating rhinovirus-related exacerbations and preventing lung disease progression in COPD |
3 | Maturu (2018) [22] | 24/Mice | 6 days/N | Intraperitoneal | Oxygen exposure | Reducing inflammation and improving alveolarization by reducing the number of neutrophils and infiltrating macrophages | Potential therapeutic value of quercetin in the prevention and/or treatment of BPD |
4 | Oka (2019) [24] | 18/Rat | 8 weeks/250 | Intratracheal instillation | Amiodarone | Quercetin reduces the number of macrophages and inflammation | Quercetin significantly suppressed amiodarone-induced toxicity in lung tissues |
5 | Boots (2020) [19] | 44/Mice | 12 weeks/N | Diet enriched | Bleomycin | Quercetin has anti-fibrogenic and anti-inflammatory effects on lung injury | Quercetin alone cannot improve the progression of IPF |
6 | Tiboc-Schnell (2020) [20] | 50/Rat | 20 days/110 | Intranasal | LPS | In the lungs, quercetin decreased TNF-α and IL-6 levels | Quercetin has a protective effect on the lungs |
7 | da Silva Araújo (2020) [25] | 50/Mice | 12 weeks/N | Inhalation | Cigarette smoke | Reduction of leukocyte level, oxidative stress, changes in histological pattern of lung parenchyma, and improvement of lung function | Quercetin can be an effective adjuvant to treat the effects of exposure to cigarette smoke |
8 | Ileriturk (2022) [21] | 35/Rat | Adult/- | Inhalation | Cypermethrin | An increase in the level of malondialdehyde and a decrease in the concentration of glutathione, the activity of glutathione peroxidase, superoxide dismutase, and catalase. | Lung injury associated with cypermethrin toxicity can be protected by the administration of quercetin |
9 | Chen (2022) [15] | 36/Rat | 8 weeks/220 | Inhalation | Paraquat | Quercetin-nanogel alleviated oxidative stress damage and inflammatory cytokines in ALI rats. | Inhalable quercetin-nanogel may serve as a drug delivery strategy in the treatment of ALI |