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Effect of airway vibratory mucus disintegration on clinical morbidity and management of chronic obstructive pulmonary disease patients



Chronic obstructive pulmonary disease (COPD) is the fifth cause of morbidity and mortality in the developed world and represents a substantial economic and social burden. Patients experience a progressive deterioration characterized by airflow limitation, limited and declining performance status with chronic respiratory failure, and severe systemic manifestations/complications.

Aim of study

The aim of the study was to evaluate the effect of airway vibratory mucus disintegration on clinical morbidity and management of COPD patients.

Patients and methods

This prospective study was conducted on 30 COPD patients admitted to the Chest Department, Main University Hospital in Alexandria during the period from January 2012 to November 2012. The patients were subdivided into two groups: group I included 15 patients with COPD subjected to conventional treatment and group II included 15 patients with COPD subjected to conventional treatment and mucus disintegration by mechanical vibration.


A general improvement in cough and dyspnea was observed in the two groups after treatment. Six-minute walking distance was improved after treatment in both groups, but the improvement was statistically significant only in group II after treatment. Partial pressure of oxygen in the blood (PaO2), partial pressure of CO2 in the blood (PaCO2), and bicarbonate (HCO3) and oxygen saturation (SaO2) showed significant differences before and after treatment among group II patients. The total duration of hospital stay was significantly lower in group II patients than in group I patients.


We can conclude that there were no adverse effects. Flutter is simple to use, inexpensive, and fully portable, and once the patient and family are instructed its use, it does not require the assistance of a caregiver. Egypt J Broncho 2013 7:43–49


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Correspondence to Ahmed Y. Gad MD.

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Gad, A.Y., El-Shafe, S.A. Effect of airway vibratory mucus disintegration on clinical morbidity and management of chronic obstructive pulmonary disease patients. Egypt J Bronchol 7, 43–49 (2013).

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  • COPD
  • mucous vibration
  • airflow limitation
  • rehabilitation
  • smoking cessation