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Pulmonary hypertension in idiopathic pulmonary fibrosis

Egyptian Journal of Bronchology volume 8, pages 23–31 (2014)Cite this article

Abstract

Background

Pulmonary hypertension (PH) is a common finding in patients with idiopathic pulmonary fibrosis ( IPF) and is associated with increased morbidity and mortality.

Aim

This study was designed to detect the prevalence of PH in patients with IPF and to determine the correlation between pulmonary function test (PFT) parameters, radiological and echocardiographic findings, and PH among these patients. In addition, the effect of therapy for 1 month (long-term oxygen therapy ± drugs) on PH was evaluated.

Patients and methods

PFTs, the composite physiologic index, multidetector chest computed tomography, and echocardiography were performed on 60 IPF patients (10 men and 50 women, mean age 51 years). Fifteen healthy age-matched and sex-matched volunteers were also studied as a control group.

Results

PH was present in 46 (76.6%) patients of IPF. There was a high negative correlation between parameters of PFTs and composite physiologic index and the mean pulmonary arterial pressure ( mPAP). In contrast, there was a significant positive correlation between mPAP and main pulmonary artery diameter on computed tomography. There was also a positive correlation between echocardiographic findings and mPAP. There was no significant improvement of PH between those patients treated with drugs and oxygen and those on oxygen therapy alone.

Conclusion

PH is common in patients with IPF. There is an inverse relationship between lung function measures and PH and a direct one with radiological and echocardiographic findings. The short-term use of oxygen therapy with or without drugs had no effect on PH in patients with IPF. Egypt J Broncho 2014 8:23–31

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Author information

Authors and Affiliations

  1. Department of Chest Diseases, Assiut University, Minia, Egypt

    Amany Omar Mohammed

  2. Departments of Chest Diseases, 6111, Minia, Egypt

    Azza Farag Said El-Tooney MD & Zainab Hassan Saied

  3. Cardiology Radiology, Faculty of Medicine, Minia University, Minia, Egypt

    Nasser Mohammed Taha

  4. Cardiology Radiology, Faculty of Medicine, Minia University, Minia, Egypt

    Hosny Sayed Abdel Ghani

Authors
  1. Amany Omar Mohammed
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  2. Azza Farag Said El-Tooney MD
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  3. Nasser Mohammed Taha
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  4. Hosny Sayed Abdel Ghani
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  5. Zainab Hassan Saied
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Corresponding author

Correspondence to Azza Farag Said El-Tooney MD.

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Mohammed, A.O., El-Tooney, A.F.S., Taha, N.M. et al. Pulmonary hypertension in idiopathic pulmonary fibrosis. Egypt J Bronchol 8, 23–31 (2014). https://doi.org/10.4103/1687-8426.137348

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  • DOI: https://doi.org/10.4103/1687-8426.137348

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