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The Egyptian Journal of Bronchology
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A study of IL-6, IL-8, and TNF-α as inflammatory markers in COPD patients

Egyptian Journal of Bronchology volume 8, pages 91–99 (2014)Cite this article

Abstract

Aim

To assess the diagnostic value of interleukin 6 (IL-6), IL-8 and tumor necrosis factor-α (TNF-α) as inflammatory markers in chronic obstructive pulmonary disease (COPD) patients.

Methods and results

IL-6, IL-8 and TNF-α levels were measured by ELISA in the serum and the bronchoalveolar lavage (BAL) in 10 control participants and 25 mild and moderate COPD patients, whereas 25 patients with severe COPD were studied for the serum level of these inflammatory biomarkers.

The mean value and SD of BAL and serum IL-6, IL-8 and TNF-α levels were significantly higher in COPD patients when compared with control participants; the serum level of these biomarkers were also significantly higher in severe compared with mild and moderate COPD patients.

Conclusion

Increased srum and/or BAL IL-6, IL-8 and TNF-α can be used as biomarkers of the systemic inflammatory response in COPD patients, and their levels are correlated with the severity of COPD. Egypt J Broncho 2014 8:91–99

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Authors and Affiliations

  1. Chest and Clinical Pathology Department, Kafr EL-Shek Chest Hospital, Tanta University, Tanta, Egypt

    Wafaa S. El-Shimy, Ayman S. El-Dib, Hala M. Nagy & Wael Sabry

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  1. Wafaa S. El-Shimy
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  2. Ayman S. El-Dib
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  3. Hala M. Nagy
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  4. Wael Sabry
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Correspondence to Ayman S. El-Dib.

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El-Shimy, W.S., El-Dib, A.S., Nagy, H.M. et al. A study of IL-6, IL-8, and TNF-α as inflammatory markers in COPD patients. Egypt J Bronchol 8, 91–99 (2014). https://doi.org/10.4103/1687-8426.145698

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