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The Egyptian Journal of Bronchology
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Assessment of respiratory muscles’ performance in patients with chronic renal failure immediately before and after hemodialysis

Egyptian Journal of Bronchology volume 8, pages 100–107 (2014)Cite this article

Abstract

Background

Physiological abnormalities are frequent in the skeletal muscle structure of patients with chronic renal failure (CRF), and their main signs are fatigue, muscular weakness, and low exercise tolerance. Respiratory muscular weakness may lead to hemodialysis; maximum respiratory pressure measurements may help in early diagnosis and to decide on therapeutic interventions for these patients.

Objective

To assess the respiratory muscle performance by measuring the maximum inspiratory pressure (PImax) and the maximum expiratory pressure (PEmax) in patients with CRF immediately before and after hemodialysis (HD).

Patients and methods

Sixty patients with CRF were recruited and divided into two groups: group 1 included patients undergoing HD and group 2 included those receiving conservative treatment. All the patients were subjected to arterial blood gases, pulmonary function test, PImax, and PEmax.

Results

There was a significant difference between hemogasometric parameters (pH, PaCO2), PImax%, and spirometric parameters (FEV1/FVC%, FEV1%, and MMEFR) before and after dialysis. There was, moreover, a significant difference in hemogasometric parameters (PaCO2, PaO2), PImax%, and spirometric parameters (FVC%, FEV1%, and MMEFR) between CRF patients receiving conservative treatment and those under dialysis before the dialysis session. Furthermore, there was a significant difference in hemogasometric parameters (pH, PCO2, PO2), PImax%, and spirometric parameters (FVC, FEV1%, FVC, and MMEFR) between both groups. There was a significant inverse relationship between pH and PEmax% in group 2 and between PImax% and MMEFR FEV1 in group 1 before dialysis. In contrast, a significant direct relationship was found between PaO2 and MMEFR in group 2, between PImax% and FEV1 in group 1 before dialysis as well as between PEmax% and FVC/FEV1 in group 1 before dialysis.

Conclusion

There was an obvious decrease in the respiratory muscle performance, arterial blood gases, and spirometric measurements in patients with CRF, both those who were receiving conservative treatment and those under HD, but this decrease was more apparent in those under HD. Egypt J Broncho 2014 8:100–107

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Authors and Affiliations

  1. Department of Pulmonary Medicine, Ain Shams University, Egypt

    L. Ashour, K. Wagih MD, H. Atef, W. Bichari & D. Fathya

  2. Department of Nephrology, Faculty of Medicine, Ain Shams University, Egypt

    W. Bichari

Authors
  1. L. Ashour
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  2. K. Wagih MD
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  3. H. Atef
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  4. W. Bichari
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  5. D. Fathya
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Corresponding author

Correspondence to K. Wagih MD.

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Ashour, L., Wagih, K., Atef, H. et al. Assessment of respiratory muscles’ performance in patients with chronic renal failure immediately before and after hemodialysis. Egypt J Bronchol 8, 100–107 (2014). https://doi.org/10.4103/1687-8426.145699

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  • DOI: https://doi.org/10.4103/1687-8426.145699

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