- Case report
- Open access
- Published:
A rare presentation of a rare disease
Egyptian Journal of Bronchology volume 8, pages 173–174 (2014)
Abstract
Background
Castleman’s disease, a rare condition of uncertain etiology, is associated with lymphoproliferation. It is histologically and prognostically distinct from malignant lymph node hyperplasia.
Case presentation
We report a case of a female patient who presented with interstitial lung disease and mediastinal lymphadenopathy, not responding to usual treatment.
Conclusion
Definitive histological diagnosis in patients with lymphadenopathic presentation associated with systemic symptoms is important to differentiate Castleman’s disease from malignant lymphoma.
References
Barrie JR, English JC, Müller N. Castleman’s disease of the lung: radiographic, high-resolution CT, and pathologic findings. Am J Roentgenol 1996; 166:1055–1056.
Denenberg S, Levine PA. Castleman’s disease — the lymphoma impostor. Laryngoscope 1984; 94:601–604.
Patel U, Forte V, Taylor G, Sirkin W. Castleman’s disease as a rare cause of a neck mass in a child. J Otolaryngol 1998; 27:171–173.
Summerfield GP, Taylor W, Bellingham AJ, Goldsmith HJ. Hyaline-vascular variant of angiofollicular lymph node hyperplasia with systemic manifestations and response to corticosteroids. J Clin Pathol 1983; 36:1005–1011.
Beck JT, Hsu SM, Wijdenes J, Bataille R, Klein B, Vesole D, et al. Brief report: alleviation of systemic manifestations of Castleman’s disease by monoclonal anti-interleukin-6 antibody. N Engl J Med 1994; 330:602–605.
Matsuyama M, Suzuki T, Tsuboi H, Ito S, Mamura M, Goto D, et al. Anti-interleukin-6 receptor antibody (tocilizumab) treatment of multicentric Castleman’s disease. Intern Med 2007; 46:771–774.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Ibraheem, T. A rare presentation of a rare disease. Egypt J Bronchol 8, 173–174 (2014). https://doi.org/10.4103/1687-8426.145724
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.4103/1687-8426.145724