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The Egyptian Journal of Bronchology
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  • Interstitial lung diseases and lung in systemic diseases
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Factors predicting pulmonary hypertension in idiopathic pulmonary fibrosis patients

Egyptian Journal of Bronchology volume 9, pages 55–58 (2015)Cite this article

Abstract

Context

Pulmonary hypertension (PH) is a common complication of idiopathic pulmonary fibrosis (IPF) and an important pathophysiologic mechanism of exercise intolerance and poor quality of life in these patients.

Aims

The aims of this study were to assess predictors of PH in IPF from both resting pulmonary function test (PFT) and cardiopulmonary exercise testing (CPET) parameters and to establish cut-off values from resting PFT and CPET parameters for the prediction of PH.

Settings and design

This was a randomized, double-blind, and prospective study.

Patients and methods

Thirty-five patients with stable IPF were assessed in terms of resting pulmonary functions, arterial blood gases (ABG), echocardiography, and incremental CPET. Patients were classified into a PH group and a non-pulmonary-hypertension group.

Statistical analysis

Both groups were compared in terms of resting PFT and CPET parameters. A receiver operating characteristic curve was constructed to establish cut-off values for the prediction of PH.

Results

PH was observed in 13 (37.14%) patients. There were no significant differences between both groups in age and sex. forced vital capacity (FVC)%, forced expiratory volume in one second (FEV1)%, inspiratory capacity, resting and exercise partial arterial oxygen tension (PaO2) and arterial oxygen saturation (SaO2), and oxygen consumption (VO2%) were significantly reduced in the PH group, whereas the dyspnea score, resting and exercise PaCO2, respiratory frequency, and minute ventilation were significantly increased in the PH group. The receiver operating characteristic curve showed that resting SaO2 of 92.9% or less and exercise SaO2 of 87% or less had sensitivity of 84.6, and 100%, and specificity of 90.9 and 81.8%, respectively.

Conclusion

Marked deterioration in resting PFT, exercise parameters, and SaO2 can predict PH in IPF patients.

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Authors and Affiliations

  1. Department of Chest Diseases, Assiut University Hospital, Assiut University, Assiut, 71111, Egypt

    Samiaa H. Sadek MD

  2. Department of Internal Medicine, Assiut University Hospital, Assiut University, Assiut, Egypt

    Soheir M. Kasem

Authors
  1. Samiaa H. Sadek MD
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  2. Soheir M. Kasem
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Corresponding author

Correspondence to Samiaa H. Sadek MD.

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Sadek, S.H., Kasem, S.M. Factors predicting pulmonary hypertension in idiopathic pulmonary fibrosis patients. Egypt J Bronchol 9, 55–58 (2015). https://doi.org/10.4103/1687-8426.153607

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  • DOI: https://doi.org/10.4103/1687-8426.153607

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