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The Egyptian Journal of Bronchology
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  • Interstitial lung diseases and lung in systemic diseases
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Serum surfactant protein D as a prognostic factor in idiopathic pulmonary fibrosis

Egyptian Journal of Bronchology volume 9, pages 64–68 (2015)Cite this article

Abstract

Background/aim

The aim of this study was to investigate the possible role of surfactant protein D (SP-D) in the pathogenesis and the prognosis of idiopathic pulmonary fibrosis (IPF).

Materials and methods

This study was performed on 10 healthy volunteers (group 1) and 30 patients from the Chest Diseases Department, Kasr El-Aini Hospital, who were divided into three groups: group 2 consisted of 10 patients with IPF receiving steroids; group 3 consisted of 10 patients with IPF not receiving steroids; and group 4 consisted of 10 patients with chronic chest diseases other than IPF and not receiving steroids. All patients underwent full history taking, thorough clinical examination, chest radiography and high-resolution computed tomography of the chest, pulmonary function testing, and estimation of SP-D by enzyme-linked immunosorbent assay.

Results

There was no statistical significance in the mean age of the four included groups. With regard to smoking in patients in groups 2, 3, and 4, there was no statistical significance in the duration or the number of cigarettes smoked per day. There was a significant decrease in FEV1, FVC, and FEV1/FVC in groups 2, 3, and 4 compared with the control group (group 1). SP-D shows a significant increase in groups 2, 3, and 4 compared with the control group, and also shows a significant increase in IPF patients not receiving steroids (group 3) compared with IPF patients receiving steroids (group 2) and patients with chronic chest diseases (group 4). A negative correlation was found between SP-D and FEV1, FVC, and FEV1/FVC. No correlation was found between SP-D, age, the duration of smoking, or the number of cigarettes smoked per day.

Conclusion

The SP-D assay may indicate the rate of decline in the pulmonary function in cases of IPF and in the follow-up of disease progress. It may also assist in making clinical choices for the therapeutic management of patients with IPF.

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Authors and Affiliations

  1. Department of Biochemistry, Cairo University, Cairo, Egypt

    Dawalat El-Miligy & Laila Rashed

  2. Department of Chest Diseases, Cairo University, 5, Makrize Street, Zamalek, Cairo, 11211, Egypt

    Mohamed W. Zakaria

  3. Department of Biochemistry, 6th October University, Egypt

    Haidi Abu-Hussein

Authors
  1. Dawalat El-Miligy
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  2. Mohamed W. Zakaria
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  3. Laila Rashed
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  4. Haidi Abu-Hussein
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Corresponding author

Correspondence to Mohamed W. Zakaria.

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El-Miligy, D., Zakaria, M.W., Rashed, L. et al. Serum surfactant protein D as a prognostic factor in idiopathic pulmonary fibrosis. Egypt J Bronchol 9, 64–68 (2015). https://doi.org/10.4103/1687-8426.153654

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  • DOI: https://doi.org/10.4103/1687-8426.153654

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