Skip to main content

Study of serum leptin level in obese and nonobese asthmatic patients

Abstract

Aim

The aim of the study was to investigate serum leptin levels in obese and nonobese asthmatic patients and its change during acute attack and in remission, as well as its relation to the changes in pulmonary functions.

Methods

The study was carried out on 55 participants (40 asthmatic patients and 15 controls) who were divided according to BMI into obese [(BMI >30 kg/m2), 20 asthmatic patients and eight controls] and nonobese [(BMI <25 kg/m2), 20 asthmatic patients and seven controls]. All participants were subjected to calculation of BMI, pulmonary function tests, and morning serum leptin level estimation (after at least 8 h of fasting).

Results

Serum leptin levels (mean in ng/ml) in obese controls (64 ng/ml) and obese asthmatic patients (80.4 ng/ml during remission and 92.9 during exacerbation) were significantly higher than that in nonobese controls (6.3 ng/ml) and nonobese asthmatic patients (33.8 ng/ml during remission and 48.8 during exacerbation). There was a significant (r = −0.456 and P ≤ 0.05) negative correlation between the change in serum leptin (ng/ml) and the change in forced vital capacity (FVC) (% Predicted) and forced expiratory volume in first second (FEV1) (% Predicted) in obese asthmatic patients, but not in nonobese asthmatic patients. There was a significant positive correlation between BMI (kg/m2) and serum leptin levels (ng/ml) in obese (r = 0.712 and P ≤ 0.05) and nonobese (r = 0.747 and P ≤ 0.05) controls and a higher significant positive correlation in obese (r = 0.94 during exacerbation and r = 0.833 during remission, P ≤ 0.001) and nonobese (r = 0.687 during exacerbation, P ≤ 0.001 and r = 0.488 during remission, P ≤ 0.05) asthmatic patients.

Conclusion

Serum leptin levels were higher in all asthmatic patients (more during exacerbation) compared with controls and the values were higher in obese than in nonobese asthmatic patients with a significant negative correlation between the change in serum leptin and the change in FEV1 and FVC in obese asthmatic patients. These findings indicate that leptin is involved in asthma inflammation.

References

  1. Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008; 31:143–178.

    Article  CAS  Google Scholar 

  2. Chen Y, Dales R, Jiang Y. The association between obesity and asthma is stronger in nonallergic than allergic adults. Chest 2006; 130:890–895.

    Article  Google Scholar 

  3. Peters-Golden M, Swern A, Bird SS, Hustad CM, Grant E, Edelman JM. Influence of body mass index on the response to asthma controller agents. Eur Respir J 2006; 27:495–503.

    Article  CAS  Google Scholar 

  4. Figueroa-Munoz JI, Chinn S, Rona RJ. Association between obesity and asthma in 4–11 year old children in the UK. Thorax 2001; 56:133–137.

    Article  CAS  Google Scholar 

  5. Shore SA, Rivera-Sanchez YM, Schwartzman IN, Johnston RA. Responses to ozone are increased in obese mice. J Appl Physiol 2003; 95:938–945.

    Article  CAS  Google Scholar 

  6. Shore SA, Schwartzman IN, Mellema MS, Flynt L, Imrich A, Johnston RA. Effect of leptin on allergic airway responses in mice. J Allergy Clin Immunol 2005; 115:103–109.

    Article  CAS  Google Scholar 

  7. F Lago, C Dieguez, J Gómez-Reino, O Gualillo. Adipokines as emerging mediators of immune response and inflammation. Nat Clin Pract Rheumatol 2007; 3:716–724.

    Article  CAS  Google Scholar 

  8. DA Beuther. Obesity and asthma. Clin Chest Med 2009; 30:479–488.

    Article  Google Scholar 

  9. Chen Y, Dales R, Tang M, Krewski D. Obesity may increase the incidence of asthma in women but not in men: longitudinal observations from the Canadian National Population Health Surveys. Am J Epidemiol 2002; 155:191–197.

    Article  Google Scholar 

  10. Leynaert B, Bousquet J, Henry C, Liard R, Neukirch F. Is bronchial hyperresponsiveness more frequent in women than in men? A population-based study. Am J Respir Crit Care Med 1997; 156:1413–1420.

    Article  CAS  Google Scholar 

  11. Torén K, Hermansson BA. Incidence rate of adult-onset asthma in relation to age, sex, atopy and smoking: a Swedish population-based study of 15813 adults. Int J Tuberc Lung Dis 1999; 3:192–197.

    PubMed  Google Scholar 

  12. K Tantisira, S Weiss. Complex interactions in complex traits: obesity and asthma. Thorax 2001; 56:ii64–ii73.

    PubMed  PubMed Central  Google Scholar 

  13. Camargo CA Jr, Weiss ST, Zhang S, Willett WC, Speizer FE. Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Arch Intern Med 1999; 159:2582–2588.

    Article  Google Scholar 

  14. Haynes WG, Morgan DA, Djalali A, Sivitz WI, Mark AL. Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic. Hypertension 1999; 33:542–547.

    Article  CAS  Google Scholar 

  15. Guler N, Kirerleri E, Ones U, Tamay Z, Salmayenli N, Darendeliler F. Leptin: does it have any role in childhood asthma? J Allergy Clin Immunol 2004; 114:254–259.

    Article  CAS  Google Scholar 

  16. Mai XM, Böttcher MF, Leijon I. Leptin and asthma in overweight children at 12 years of age. Pediatr Allergy Immunol 2004; 15:523–530.

    Article  Google Scholar 

  17. Sood A, Ford ES, Camargo CA Jr. Association between leptin and asthma in adult. Thorax 2006; 61:300–305.

    Article  CAS  Google Scholar 

  18. Kilic H, Oguzulgen IK, Bakir F, Turktas H. Asthma in obese women: outcomes and factors involved. J Investig Allergol Clin Immunol 2011; 21:290–296.

    CAS  PubMed  Google Scholar 

  19. Sarraf P, Frederich RC, Turner EM, Ma G, Jaskowiak NT, Rivet DJ 3rd, et al. Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J Exp Med 1997; 185:171–175.

    Article  CAS  Google Scholar 

  20. Faggioni R, Fantuzzi G, Fuller J, et al. IL-1 beta mediates leptin induction during inflammation. Am J Physiol 1998; 274:R204–R208.

    CAS  PubMed  Google Scholar 

  21. Gosset P, Tsicopoulos A, Wallaert B, Joseph M, Capron A, Tonnel AB. Tumor necrosis factor alpha and interleukin-6 production by human mononuclear phagocytes from allergic asthmatics after IgE-dependent stimulation. Am Rev Respir Dis 1992; 146:768–774.

    Article  CAS  Google Scholar 

  22. Kirchgessner TG, Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes. J Clin Invest 1997; 100:2777–2782.

    Article  CAS  Google Scholar 

  23. JHJ Vernooy, NDJ Ubag, GG Brusselle, J Tavernier, BT Suratt, GF Joos, et al. Leptin as regulator of pulmonary immune responses: involvement in respiratory diseases. Pulm Pharmacol Ther 2013; 26:464–472.

    Article  CAS  Google Scholar 

  24. Sin DD, Man SF. Impaired lung function and serum leptin in men and women with normal body weight: a population based study. Thorax 2003; 58:695–698.

    Article  CAS  Google Scholar 

  25. King GG, Brown NJ, Diba C, Thorpe CW, Muñoz P, Marks GB, et al. The effects of body weight on airway calibre. Eur Respir J 2005; 25:896–901.

    Article  CAS  Google Scholar 

  26. Hancox RJ, Milne BJ, Poulton R, Taylor DR, Greene JM, McLachlan CR, et al. Sex differences in the relation between body mass index and asthma and atopy in a birth cohort. Am J Respir Crit Care Med 2005; 171:440–445.

    Article  Google Scholar 

  27. Weiss ST. Obesity: insight into the origins of asthma. Nat Immunol 2005; 6:537–539.

    Article  CAS  Google Scholar 

  28. Weiss ST, Shore S. Obesity and asthma: directions for research. Am J Respir Crit Care Med 2004; 169:963–968.

    Article  Google Scholar 

  29. Shore SA. Obesity and asthma: lessons from animal models. J Appl Physiol 2007; 102:516–528.

    Article  CAS  Google Scholar 

  30. Shore SA. Obesity and asthma: possible mechanisms. J Allergy Clin Immunol 2008; 121:1087–1093. quiz 1094–1085

    Article  Google Scholar 

  31. Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 2006; 17:4–12.

    CAS  PubMed  Google Scholar 

  32. Matarese G, La Cava A, Sanna V, Lord GM, Lechler RI, Fontana S, et al. Balancing susceptibility to infection and autoimmunity: a role for leptin? Trends Immunol 2002; 23:182–187.

    Article  CAS  Google Scholar 

  33. Kim JH, Kim BS, Lee SY, Seo JH, Shim JY, Hong TJ, et al. Different IL-5 and IFN-gamma production from peripheral blood T-cell subsets in atopic and nonatopic asthmatic children. J Asthma 2004; 41:869–876.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Nabil A. Abdelghaffar Hibah MD.

Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Mohammed, E.A., Omar, M.M., Hibah, N.A.A. et al. Study of serum leptin level in obese and nonobese asthmatic patients. Egypt J Bronchol 9, 118–124 (2015). https://doi.org/10.4103/1687-8426.158038

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.4103/1687-8426.158038

Keywords

  • asthma
  • BMI
  • leptin
  • obese
  • pulmonary function tests