Skip to main content

Effect of continuous positive airway pressure on oxidative stress accompanied by obstructive sleep apnea

Abstract

Introduction

In obstructive sleep apnea (OSA), there is increased oxidative stress.

Aim of this work

This study aimed to examine the effect of continuous positive airway pressure (CPAP) on oxidative stress occurring in OSA.

Participants and methods

The present study was carried out on 40 individuals classified into four groups: group I included 10 control participants, group II included 10 obese individuals without OSA, group III included 10 patients with mild to moderate OSA, and group IV included 10 patients with severe OSA. Sleep study was carried out, and Thiobarbituric acid-reactive substance and superoxide dismutase enzyme were measured.

Results

Thiobarbituric acid-reactive substance was significantly increased, but superoxide dismutase was significantly decreased in group IV, and CPAP led to an improvement in this condition.

Conclusion

OSA leads to increased oxidative stress that improved with the use of CPAP.

References

  1. Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A, et al. Sleep apnea and cardiovascular disease: an American Heart Association/ American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing. J Am Coll Cardiol 2008; 52:686–717.

    Article  Google Scholar 

  2. Punjabi NM. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc 2008; 5:136–143.

    Article  Google Scholar 

  3. Lopez-Jimenez F, SertKuniyoshi FH, Gami A, Somers VK. Obstructive sleep apnea: implications for cardiac and vascular disease. Chest 2008; 133:793–804.

    Article  Google Scholar 

  4. The Report of an American Academy of Sleep Medicine. Task Force. Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. Sleep 1999; 22:667–689.

    Article  Google Scholar 

  5. McNicholas WT. Diagnosis of obstructive sleep apnea in adults. Proc Am Thorac Soc 2008; 5:154–160.

    Article  Google Scholar 

  6. Ayappa I, Rapoport DM. The upper airway in sleep: physiology of the pharynx. Sleep Med Rev 2003; 7:9–33.

    Article  Google Scholar 

  7. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 1991; 14:540–545.

    Article  CAS  Google Scholar 

  8. Kim JH, Kwon MS, Song HM, Lee BJ, Jang YJ, Chung YS. Compliance with positive airway pressure treatment for obstructive sleep apnea. Clin Exp Otorhinolaryngol 2009; 2: 90–96.

    Article  Google Scholar 

  9. Vaziri ND, Dicus M, Ho ND, Boroujerdi-Rad L, Sindhu RK. Oxidative stress and dysregulation of superoxide dismutase and NADPH oxidase in renal insufficiency. Kidney Int 2003; 63:179–185.

    Article  CAS  Google Scholar 

  10. Yamauchi M, Nakano H, Maekawa J, Okamoto Y, Ohnishi Y, Suzuki T, Kimura H. Oxidative stress in obstructive sleep apnea. Chest 2005; 127:1674–1679.

    Article  CAS  Google Scholar 

  11. Suzuki YJ, Jain V, Park AM, Day RM. Oxidative stress and oxidant signaling in obstructive sleep apnea and associated cardiovascular diseases. Free Radic Biol Med 2006; 40:1683–1692.

    Article  CAS  Google Scholar 

  12. Kangralkar VA, Patil SD, Bandivadekar RM. Oxidative stress and diabetes: a review. Int J Pharm Appl 2010; 1: 38–45.

    CAS  Google Scholar 

  13. Faure P, Tamisier R, Baguet JP, Favier A, Halimi S, Lévy P, Pépin JL. Impairment of serum albumin antioxidant properties in obstructive sleep apnoea syndrome. Eur Respir J 2008; 31:1046–1053.

    Article  CAS  Google Scholar 

  14. Lavie L, Vishnevsky A, Lavie P. Evidence for lipid peroxidation in obstructive sleep apnea. Sleep 2004; 27:123–128.

    PubMed  Google Scholar 

  15. Wysocka E, Cofta S, Cymerys M, Gozdzik J, Torlinski L, Batura-Gabryel H. The impact of the sleep apnea syndrome on oxidant-antioxidant balance in the blood of overweight and obese patients. J Physiol Pharmacol 2008; Suppl 6: 761–769.

  16. Liu HG, Liu K, Zhou YN, Xu YJ. Relationship between reduced nicotinamide adenine dinucleotide phosphate oxidase subunit p22 phox gene polymorphism and obstructive sleep apnea-hypopnea syndrome in the Chinese Han population. Chin Med J 2009; 122:1369–1374.

    CAS  PubMed  Google Scholar 

  17. Deegan PC, McNicholas WT. Predictive value of clinical features for the obstructive sleep apnoea syndrome. Eur Respir J 1996; 9:117–124.

    Article  CAS  Google Scholar 

  18. Ramanathan L, Gulyani S, Nienhuis R, Siegel JM. Sleep deprivation decreases superoxide dismutase activity in rat hippocampus and brainstem. Neuroreport 2002; 13:1387–1390.

    Article  CAS  Google Scholar 

  19. Alzoghaibi MA, Bahammam AS. Lipid peroxides, superoxide dismutase and circulating IL-8 and GCP-2 in patients with severe obstructive sleep apnea: a pilot study. Sleep Breath 2005; 9:119–126.

    Article  Google Scholar 

  20. Svatikova A, Wolk R, Lerman LO, Juncos LA, Greene EL, McConnell JP, et al. Oxidative stress in obstructive sleep apnoea. Eur Heart J 2005; 26:2435–2439.

    Article  CAS  Google Scholar 

  21. Wali SO, Bahammam AS, Massaeli H, Pierce GN, Iliskovic N, Singal PK, Kryger MH. Susceptibility of LDL to oxidative stress in obstructive sleep apnea. Sleep 1998; 21:290–296.

    CAS  PubMed  Google Scholar 

  22. Christou K, Moulas AN, Pastaka C, Gourgoulianis KI. Antioxidant capacity in obstructive sleep apnea patients. Sleep Med 2003; 4:225–228.

    Article  Google Scholar 

  23. Singh TD, Patial K, Vijayan VK, Ravi K. Oxidative stress and obstructive sleep apnoea syndrome. Indian J Chest Dis Allied Sci 2009; 51:217–224.

    CAS  PubMed  Google Scholar 

  24. Alzoghaibi MA, Bahammam AS. The effect of one night of continuous positive airway pressure therapy on oxidative stress and antioxidant defense in hypertensive patients with severe obstructive sleep apnea. Sleep Breath 2012; 16:499–504.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Basem I. El-Shafey MD.

Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

El-Kholy, M.G., El-Shafey, B.I., Hantera, M.S. et al. Effect of continuous positive airway pressure on oxidative stress accompanied by obstructive sleep apnea. Egypt J Bronchol 9, 192–197 (2015). https://doi.org/10.4103/1687-8426.158092

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.4103/1687-8426.158092

Keywords

  • continuous positive airway pressure
  • obstructive sleep apnea
  • superoxide dismutase
  • thiobarbituric acid-reactive substance