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Effect of continuous positive airway pressure on oxidative stress accompanied by obstructive sleep apnea



In obstructive sleep apnea (OSA), there is increased oxidative stress.

Aim of this work

This study aimed to examine the effect of continuous positive airway pressure (CPAP) on oxidative stress occurring in OSA.

Participants and methods

The present study was carried out on 40 individuals classified into four groups: group I included 10 control participants, group II included 10 obese individuals without OSA, group III included 10 patients with mild to moderate OSA, and group IV included 10 patients with severe OSA. Sleep study was carried out, and Thiobarbituric acid-reactive substance and superoxide dismutase enzyme were measured.


Thiobarbituric acid-reactive substance was significantly increased, but superoxide dismutase was significantly decreased in group IV, and CPAP led to an improvement in this condition.


OSA leads to increased oxidative stress that improved with the use of CPAP.


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Correspondence to Basem I. El-Shafey MD.

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El-Kholy, M.G., El-Shafey, B.I., Hantera, M.S. et al. Effect of continuous positive airway pressure on oxidative stress accompanied by obstructive sleep apnea. Egypt J Bronchol 9, 192–197 (2015).

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  • continuous positive airway pressure
  • obstructive sleep apnea
  • superoxide dismutase
  • thiobarbituric acid-reactive substance