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Organizing pneumonia causing severe respiratory failure as a complication of interferon-α therapy

Egyptian Journal of Bronchology volume 10, pages 73–75 (2016)Cite this article

Abstract

Chronic hepatitis C infection is highly prevalent in Egypt. Pegylated interferon-α (in addition to ribavirin) is the standard medication and it is increasingly being used. Despite being very uncommon, interferon therapy has been associated with a plethora of pleuropulmonary complications ranging from mild asthma exacerbation to acute respiratory distress syndrome (ARDS) and death. This is a report of a case of organizing pneumonia occurring in the course of interferon therapy that has been complicated with severe respiratory failure. The pulmonary lesions have miraculously resolved after 10 days of corticosteroid therapy.

References

  1. Frank C, Mohamed MK, Strickland GT, Lavanchy D, Arthur RR, Magder LS, et al. The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt. Lancet 2000; 355:887–891.

    Article  CAS  Google Scholar 

  2. Slavenburg S, Heijdra YF, Drenth JP. Pneumonitis as a consequence of (peg)interferon-ribavirin combination therapy for hepatitis C: a review of the literature. Dig Dis Sci 2010; 55:579–585.

    Article  CAS  Google Scholar 

  3. Atug O, Akin H, Alahdab YO, Ceyhan B, Tozun N, Ozdogan O. Interstitial pneumonitis associated with pegylated interferon-alpha 2a and ribavirin for chronic hepatitis C infection: a case report. Cases J 2009; 2:6464.

    Article  Google Scholar 

  4. Midturi J, Sierra-Hoffman M, Hurley D, Winn R, Beissner R, Carpenter J. Spectrum of pulmonary toxicity associated with the use of interferon therapy for hepatitis C: case report and review of the literature. Clin Infect Dis 2004;39:1724–1729.

    Article  Google Scholar 

  5. Abdi EA, Nguyen GK, Ludwig RN, Dickout WJ. Pulmonary sarcoidosis following interferon therapy for advanced renal cell carcinoma. Cancer 1987; 59:896–900.

    Article  CAS  Google Scholar 

  6. Kamisako T, Adachi Y, Chihara J, Yamamoto T. Interstitial pneumonitis and interferon-alfa. BMJ 1993; 306:896.

    Article  CAS  Google Scholar 

  7. Camus P. Interferon alpha/beta induced lung disease [Internet]. Pneumotox. Available at: http://www.pneumotox.com/drug/view/161/ interferon-alpha-beta/ [Last accessed on 2015 May 14].

  8. Borden EC, Parkinson D. A perspective on the clinical effectiveness and tolerance of interferon-alpha. Semin Oncol 1998; 25 (Suppl 1): 3–8.

    PubMed  CAS  Google Scholar 

  9. Al-Ghanem S, Al-Jahdali H, Bamefleh H, Khan AN. Bronchiolitis obliterans organizing pneumonia: pathogenesis, clinical features, imaging and therapy review. Ann Thorac Med 2008; 3:67–75.

    Article  Google Scholar 

  10. Kim SJ, Lee KS, Ryu YH, Yoon YC, Choe KO, Kim TS, Sung KJ. Reversed halo sign on high-resolution CT of cryptogenic organizing pneumonia: diagnostic implications. Am J Roentgenol 2003; 180: 1251–1254.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Chest Diseases, Faculty of Medicine, Alexandria University, Khartoum Square, Alexandria, Azarita, 21521, Egypt

    Maged Hassan MSc & Hatem Essam

Authors
  1. Maged Hassan MSc
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  2. Hatem Essam
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Correspondence to Maged Hassan MSc.

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Hassan, M., Essam, H. Organizing pneumonia causing severe respiratory failure as a complication of interferon-α therapy. Egypt J Bronchol 10, 73–75 (2016). https://doi.org/10.4103/1687-8426.176799

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  • DOI: https://doi.org/10.4103/1687-8426.176799

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