- Original article
- Open Access
Are we with e-cigarette as a friend or against it as a foe?
Egyptian Journal of Bronchology volume 10, pages 348–354 (2016)
Background and aim
Cigarette smoking is the most important cause of avoidable premature mortality in the world, and quitting is known to reduce the risk of fatal diseases. Electronic cigarettes (e-cigarettes) are becoming increasingly popular, especially among younger adults; they may be effective aids to smoking cessation. Despite the increasing prevalence of e-cigarette use, little is known about their realworld use. The major concerns include the nicotine content and the potential harm due to the high concentrations of propylene glycol, chemicals, and other compounds found in the e-cigarette vapor. To our knowledge, there are no data on the health effects of acute use of nicotine-free e-cigarettes. The aim of this study is to evaluate the immediate effect of ecigarette vapors on airway mechanics.
Participants and methods
Forty apparently healthy neversmokers or light smokers were divided into two groups. The first group was instructed to ‘vape’ e-cigarettes with a 12-mg nicotine-filled cartridge, and the second group was asked to ‘vape’ e-cigarettes with an empty cartridge. Pulmonary function tests were assessed before and after ‘vaping’.
There was a significant increase in peripheral airway resistance of the first group, in which individuals vaped a nicotine-filled cartridge.
There is potential for more permanent changes in lung function with long-term exposure to e-cigarettes, as with cigarette smoking.
World Health Organization. WHO report on the global tobacco epidemic. Geneva: WHO; 2011. Available at: http://www.who.int/tobacco/global_report/en/.
World Health Organization. WHO framework convention on tobacco control. Geneva: WHO. Available at: http://whqlibdoc.who.int/publications/2003/9241591013.pdf. 2003.
Hughes JR, Keely J, Naud S. Shape of the relapse curve and long-term abstinence among untreated smokers. Addiction 2004; 99:29–38.
Cahn Z, Siegel M. Electronic cigarettes as a harm reduction strategy for tobacco control: a step forward or a repeat of past mistakes?. J Public Health Policy 2011; 32:16–31.
Benowitz NL, Goniewicz ML. The regulatory challenge of electronic cigarettes. JAMA 2013; 310:685–686.
Caponnetto P, Campagna D, Papale G, Russo C, Polosa R. The emerging phenomenon of electronic cigarettes. Expert Rev Respir Med 2012; 6:63–74.
Vansickel AR, Eissenberg T. Electronic cigarettes: effective nicotine delivery after acute administration. Nicotine Tob Res 2013; 15:267–270.
Thomsen T, Villebro N, Muller AM. Interventions for preoperative smoking cessation. Cochrane Database Syst Rev 2010; 7:CD002294.
Farsalinos KE, Romagna G, Allifranchini E, Ripamonti E, Bocchietto E, Todeschi S et al. Comparison of the cytotoxic potential of cigarette smoke and electronic cigarette vapor extract on cultured myocardial cells. Int J Environ Res Public Health 2013; 10:5146–5162.
Rahman MA, Hann N, Wilson A, Worrall-Carter L. Electronic cigarettes: pattern of use, health effects, use in smoking cessation and regulatory issues. Tob Induc Dis 2014; 12:21–29.
Chapman S. Should electronic cigarettes be as freely available as tobacco cigarettes? No BMJ 2013; 346:f3840.
Johns DP, Walters JA, Walters EH. Diagnosis and early detection of COPD using spirometry. J Thorac Dis 2014; 6:1557–1569.
Celli B, ZuWallack R, Wang S. Kesten S Improvement in resting inspiratory capacity and hyperinflation with tiotropium in COPD patients with increased static lung volumes. Chest 2003; 124:1743–1748.
Oppenheimer BW, Goldring RM, Berger KI. Distal airway function assessed by oscillometry at varying respiratory rate: comparison with dynamic compliance. COPD 2009; 6:162–170.
Kanda S, Fujimoto K, Komatsu Y, Yasuo M, Hanaoka M, Kubo K. Evaluation of respiratory impedance in asthma and COPD by an impulse oscillation system. Intern Med 2010; 49:23–30.
Komarow HD, Myles IA, Uzzaman A. Metcalfe DD Impulse oscillometry in the evaluation of diseases of the airways in children. Ann Allergy Asthma Immunol 2011; 106:191–199.
Anderson WJ, Lipworth BJ. Relationships between impulse oscillometry, spirometry and dyspnoea in COPD. JR Coll Physicians Edinb 2012;42:111–115.
Borrill ZL, Houghton CM, Tal-Singer R, Vessey SR, Faiferman I, Langley SJ. Singh D The use of plethysmography and oscillometry to compare long-acting bronchodilators in patients with COPD. Br J Clin Pharmacol 2008; 65:244–252.
Cooper CB. Assessment of pulmonary function in COPD. Semin Respir Crit Care Med 2005; 26:246–252.
Schermer T, MalbonW, Newbury W, Holton C, Smith M, Morgan M. Crockett A Spirometry and impulse oscillometry (IOS) for detection of respiratory abnormalities in metropolitan firefighters. Respirology 2010; 15:975–985.
Borrill ZL, Houghton CM, Woodcock AA, Vestbo J, Singh D. Measuring bronchodilation inCOPDclinical trials. Br JClinPharmacol 2005; 59:379–384.
Karrasch S, Ernst K, Behr J, Heinrich J, Huber RM, NOwak D, et al. KORA Study Group. Exhaled nitric oxide and influencing factors in a random population sample. Respir Med 2011; 105:713–718.
Farsalinos KE, Polosa R. Safety evaluation and risk assessment of electronic cigarettes as tobacco cigarette substitutes: a systematic review. Ther Adv Drug Saf 2014; 5:67–86.
Lee PN. Summary of the epidemiological evidence relating suns to health. Regul Toxicol Pharmacol 2011; 59:197–214.
Flouris AD, Chorti MS, Poulianiti KP, Jamurtas AZ, Kostikas K, Tzatzarakis MN, et al. Acute impact of active and passive electronic cigarette smoking on serum cotinine and lung function. Inhal Toxicol 2013; 25:91–101.
Chorti M, Poulianiti K, Jamurtas A, Kostikas A, Tzatzarakis MN, Vynias D. Effects of active and passive electronic and tobacco cigarette smoking on lung function. Toxicol Lett 2012; 211:43.
Vardavas CI, Anagnostopoulos N, Kougias M, Evangelopoulou V, Connolly GN. Behrakis PK Short-term pulmonary effects of using an electronic cigarette: impact on respiratory flow resistance, impedance, and exhaled nitric oxide. Chest 2012; 141:1400–1406.
Palamidas A, Gennimata SA, Kaltsakas G, Tsikrika S, Vakali S, Gratziou C, Koulousis N. Acute effect of an e-cigarette with and without nicotine on lung function. Tob Induc Dis 2014; 12:A34.
Gennimata SA, Palamidas A, Kaltsakas G, Tsikrika S, Vakali S, Gratziou C et al. Acute effect of e-cigarette on pulmonary function in healthy subjects and smokers. Eur Respir J 2012; 40(Suppl 56): 197s.
Unverdorben M, Mostert A, Munjal S, van der Bijl A, Potgieter L, Venter C, et al. Acute effect of cigarette smoking on pulmonary function. Regul Toxicol Pharmacol 2010; 57:241–246.
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Elhefny, R.A., Ali, M.A., Elessawy, A.F. et al. Are we with e-cigarette as a friend or against it as a foe?. Egypt J Bronchol 10, 348–354 (2016). https://doi.org/10.4103/1687-8426.193630
- electronic cigarette
- pulmonary function test