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Assessment of serum vitamin d levels in different severities of asthmatic patients

Abstract

Background

There is conflicting evidence about the association between low vitamin D levels and asthma.

Aim

The aim of this work was to assess the relation between the serum level of vitamin D and the asthma severity.

Patients and method

A total of 90 asthmatic patients were diagnosed of bronchial asthma clinically and functionally according to GINA guidelines classification 2012. The serum 25-hydroxy vitamin D level was measured in all the cases. The relation between the serum level of vitamin D and forced expiratory volume at 1 s (FEV1) was analyzed. Then, it was correlated to age, sex, and BMI variables.

Results

Patients were divided into three groups according to FEV1 prebronchodilators. The mean value of vitamin D was 30.43 in mild cases, whereas it was 20.27 in moderate cases, and 11.97 in severe cases. These data stated that the lower the FEV1, the greater the vitamin D deficiency levels, and this relation was statistically highly significant (P <0.001). When the three groups (of severity of airway obstruction: mild, moderate, and severe) were compared with each other, the Pvalue was less than 0.001 for all. When the three variables were added as a third cofactor (age, sex, or BMI) separately, we did not find any statistically significant effect on the results.

Conclusion

In asthmatic patients, the serum level of vitamin D was found to be directly proportional to the severity of asthma with no relation to the age, the sex, or the BMI. Further studies are recommended to assess the effect of the correction of serum vitamin D levels on the severity of asthma and asthma control.

References

  1. Global Initiative for Asthma (GINA). The global strategy for asthma management and prevention; 2015. Available at: http://www.ginasthma.org/. [Accessed 5 May 2015].

  2. Global Initiative for Asthma. Global strategy for asthma management and prevention [NIH Publication No. 02.3659]. World Health Organization/National Heart, Lung, and Blood Institute (US); 1995. Available at: http://www.ginasthma.com/. [Accessed 25 March 2014].

  3. Abd El-Menem MT, Abd Al-Aziz M, El-Guindy WM, El Banna NA. The frequency of vitamin D deficiency among asthmatic Egyptian children. Egypt J Pediatr Allergy Immunol 2013; 11:69–73.

    Google Scholar 

  4. Litonjua AA, Weiss ST. Is vitamin D deficiency to blame for the asthma epidemic? J Allergy Clin Immunol 2007; 120:1031–1035.

    CAS  Article  Google Scholar 

  5. Wang TT, Tavera-Mendoza LE, Laperriere D, Libby E, MacLeod NB, Nagai Y, et al. Large-scale in silic and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol 2005; 19:2685–2695.

    CAS  Article  Google Scholar 

  6. Marcinkowska E. A run for a membrane vitamin D receptor. Biol Signals Recept 2001; 10:341–349.

    CAS  Article  Google Scholar 

  7. Litonjua AA. Childhood asthma may be a consequence of vitamin D deficiency. Curr Opin Allergy Clin Immunol 2009; 9:202– 207.

    CAS  Article  Google Scholar 

  8. Matheu V, Bäck O, Mondoc E, Issazadeh-Navikas S. Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease. J Allergy Clin Immunol 2003; 112:585– 592.

    CAS  Article  Google Scholar 

  9. Xystrakis E, Kusumakar S, Boswell S, Peek E, Urry Z, Richards DF, et al. Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. J Clin Invest 2006; 116:146– 155.

    CAS  Article  Google Scholar 

  10. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96:1911–1930.

    CAS  Article  Google Scholar 

  11. Abd El Aaty HE, Abd El Aziz A, El Habashy M, Saafan MA, Abd El hamed SA. Assessment of serum vitamin D in patients with bronchial asthma. Egypt J Chest Dis Tuberc 2015; 64:1–5.

    Article  Google Scholar 

  12. Shebl RE, Shehata SM, Elgabry M, Ali SAI, Elsaid H. Vitamin D and phenotypes of bronchial asthma. Egypt J Chest Dis Tuberc 2013; 62:201–205.

    Article  Google Scholar 

  13. Shaaban M, Hashem M. Serum 25 hydroxy vitamin D levels in adult asthmatic patients. Egypt J Hosp Med 2012; 49:946– 952.

    Google Scholar 

  14. Sutherland ER, Goleva E, Jackson LP, Stevens AD, Leung DY. Vitamin D levels, lung function, and steroid response in adult asthma., Am J Respir Crit Care Med 2010; 181:699–704.

    CAS  Article  Google Scholar 

  15. Li F, Peng M, Jiang L, Sun Q, Zhang K, Lian F, et al. Vitamin D deficiency is associated with decreased lung function in Chinese adults with asthma. Respiration 2011; 81:469–475

    CAS  Article  Google Scholar 

  16. Alyasin S, Momen T, Kashef S, Alipour A, Amin R. The relationship between serum 25 hydroxy vitamin d levels and asthma in children. Allergy Asthma Immunol Res 2011; 3:251–255.

    CAS  Article  Google Scholar 

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Correspondence to Waleed M. El-Sorougi.

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El-Sorougi, W.M., Eissa, H.H. Assessment of serum vitamin d levels in different severities of asthmatic patients. Egypt J Bronchol 10, 261–265 (2016). https://doi.org/10.4103/1687-8426.193636

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  • DOI: https://doi.org/10.4103/1687-8426.193636

Keywords

  • 25-hydroxy vitamin D
  • asthma
  • forced expiratory volume at 1 s