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The relationship between metabolic syndrome and chronic obstructive pulmonary disease

Abstract

Background

Metabolic syndrome is a condition frequently found among individuals. It predisposes affected individuals to systemic inflammation and physical inactivity. The aim of the present study was to investigate the frequency of metabolic syndrome and C-reactive protein (CRP) levels as markers of systemic inflammation in stable chronic obstructive pulmonary disease (COPD) patients with different severity levels and in an age-matched and sex-matched control group.

Patients and methods

One hundred COPD patients and 50 controls were included in this study. The severity level in patients with COPD was determined according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages I−IV, we measured the characteristics of the metabolic syndrome and systemic inflammation (high-sensitivity Creactive protein).

Results

The frequency of metabolic syndrome was found to be higher in the patient group than in control individuals, especially in GOLD stages I and II. Abdominal obesity, hypertension, and hyperglycemia components of metabolic syndrome were significantly more prevalent in the patient group (P <0.05 for all). Increased CRP levels were higher in control and patient groups in all GOLD stages, with metabolic syndrome than without metabolic syndrome. P-values for control group and GOLD stages I–IV were 0.044, 0.483, less than 0.01, 0.048, and 0.076, respectively.

Conclusion

Metabolic syndrome is substantial among stable COPD patients, especially in the early stages (GOLD stages I−II). Abdominal obesity, hypertension, and hyperglycemia were significantly more in COPD patients with metabolic syndrome. An impaired profile of CRP levels was found in patients and control groups with metabolic syndrome than in individuals without metabolic syndrome.

References

  1. Vestbo J, Hurd SS, Agustí AG, Jones PW, Vogelmeier C, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2013; 187:347–365.

    CAS  Article  Google Scholar 

  2. Groenewegen KH, Postma DS, Hop WC, Wielders PL, Schlösser NJ, Wouters EF, COSMIC Study Group. Increased systemic inflammation is a risk factor for COPD exacerbations. Chest 2008; 133:350–357.

    Article  Google Scholar 

  3. Agustí A. Systemic effects of chronic obstructive pulmonary disease: what we know and what we don’t know (but should). Proc Am Thorac Soc 2007; 4:522–525.

    Article  Google Scholar 

  4. Mora S, Lee IM, Buring JE, Ridker PM. Association of physical activity and body mass index with novel and traditional cardiovascular biomarkers in women. JAMA 2006; 295:1412–1419.

    CAS  Article  Google Scholar 

  5. Watz H, Waschki B, Boehme C, Claussen M, Meyer T, Magnussen H. Extrapulmonary effects of chronic obstructive pulmonary disease on physical activity: a cross-sectional study. Am J Respir Crit Care Med 2008; 177:743–751.

    Article  Google Scholar 

  6. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002; 287:356–359.

    Article  Google Scholar 

  7. Dandona P, Aljada A, Chaudhuri A, Mohanty P, Garg R. Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 2005; 111:1448–1454.

    Article  Google Scholar 

  8. Ford ES, Kohl HWIII, Mokdad AH, Ajani UA. Sedentary behavior, physical activity, and the metabolic syndrome among US adults. Obes Res 2005; 13:608–614.

    Article  Google Scholar 

  9. Crisafulli E, Costi S, Luppi F, Cirelli G, Cilione C, Coletti O, et al. Role of comorbidities in a cohort of patients with COPD undergoing pulmonary rehabilitation. Thorax 2008; 63:487–492.

    CAS  Article  Google Scholar 

  10. Perloff D, Grim C, Flack J, Frohlich ED, Hill M, McDonald M, Morgenstern BZ. Human blood pressure determination by sphygmomanometry. Circulation 1993; 88(Pt 1):2460–2470.

    CAS  Article  Google Scholar 

  11. Lohmann T, Roche ARM. The Airlie (VA) consensus: standardization of anthropometric measurements. Champaign, IL: Human Kinetic Publishers; 1988. 39–80.

    Google Scholar 

  12. Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C, for the Conference Participants. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition. Circulation 2004; 109:433–438.

    Article  Google Scholar 

  13. Barnes PJ, Celli BR. Systemic manifestations and comorbidities of COPD. Eur Respir J 2009; 33:1165–1185.

    CAS  Article  Google Scholar 

  14. Moebus S, Hanisch JU, Aidelsburger P, Bramlage P, Wasem J, Jöckel KH. Impact of 4 different definitions used for the assessment of the prevalence of the metabolic syndrome in primary healthcare: The German Metabolic and Cardiovascular Risk Project (GEMCAS). Cardiovasc Diabetol 2007; 6:22.

    Article  Google Scholar 

  15. Pinto-Plata VM, Müllerova H, Toso JF, Feudjo-Tepie M, Soriano JB, Vessey RS, Celli BR. C-reactive protein in patients with COPD, control smokers and nonsmokers. Thorax 2006; 61:23–28.

    CAS  Article  Google Scholar 

  16. Wouters EF, Groenewegen KH, Dentener MA, Vernooy JH. Systemic inflammation in chronic obstructive pulmonary disease: the role of exacerbations. Proc Am Thorac Soc 2007; 4:626–634.

    CAS  Article  Google Scholar 

  17. Broekhuizen R, Wouters EF, Creutzberg EC, Schols AM. Raised CRP levels mark metabolic and functional impairment in advanced COPD. Thorax 2006; 61:17–22.

    CAS  Article  Google Scholar 

  18. Gläser S, Ittermann T, Koch B, Völzke H, Wallaschofski H, Nauck M, et al. Airflow limitation, lung volumes and systemic inflammation in a general population. Eur Respir J 2012; 39:29–37.

    Article  Google Scholar 

  19. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 2005; 115:911–919; quiz 920.

    CAS  Article  Google Scholar 

  20. Thorand B, Baumert J, Döring A, Herder C, Kolb H, Rathmann W, et al. KORA Group. Sex differences in the relation of body composition to markers of inflammation. Atherosclerosis 2006; 184:216–224.

    CAS  Article  Google Scholar 

  21. Poulain M, Doucet M, Drapeau V, Fournier G, Tremblay A, Poirier P, Maltais F. Metabolic and inflammatory profile in obese patients with chronic obstructive pulmonary disease. Chron Respir Dis 2008; 5:35–41.

    CAS  Article  Google Scholar 

  22. Fabbri LM, Luppi F, Beghé B, Rabe KF. Complex chronic comorbidities of COPD. Eur Respir J 2008; 31:204–212.

    CAS  Article  Google Scholar 

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Correspondence to Therese Ghatas.

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Ghatas, T. The relationship between metabolic syndrome and chronic obstructive pulmonary disease. Egypt J Bronchol 11, 11–15 (2017). https://doi.org/10.4103/1687-8426.198983

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Keywords

  • chronic obstructive pulmonary disease
  • C-reactive protein
  • metabolic syndrome