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Bronchoscopy as a salvage therapy in a mechanically ventilated status asthmaticus patient: A case report

Abstract

A 23-year-old male patient presented with acute exacerbation of asthma with type 2 respiratory failure. He was mechanically ventilated and started on intensive medical therapy including nebulization with β2 agonists and antimuscarinic drugs, steroids, antibiotics and magnesium sulphate as per standard protocol. As there was no response to the abovementioned line of treatment, other nonstandard therapies such as intramuscular adrenaline and ketamine were also tried but to no avail. After a meticulous literature search, bronchoscopy was planned to look for any alternative diagnoses as well as to perform bronchial toileting. The patient showed dramatic improvement after the procedure, was subsequently extubated and discharged in stable condition. This case essays the significant role of bronchoscopy in refractory status asthmaticus patients, discusses the pathophysiological mechanisms addressed by bronchoscopic toileting and, furthermore, reviews the contemporary literature for evidence in its favour.

References

  1. McFadden ER Jr. Acute severe asthma. Am J Respir Crit Care Med 2003; 168:740–759.

    Article  Google Scholar 

  2. Shapiro JM. Intensive care management of status asthmaticus. Chest 2001; 120:1439–1441.

    Article  CAS  Google Scholar 

  3. Expert Panel Report 3 (EPR-3). Guidelines for the diagnosis and management of asthma-summary report 2007. National Asthma Education and Prevention Program. J Allergy Clin Immunol 2007; 120:S94–S138.

  4. Zamanian M, Marini JJ. Pressure-flow signatures of central-airway mucus plugging. Crit Care Med 2006; 34:223–226.

    Article  Google Scholar 

  5. Kuyper LM, Paré PD, Hogg JC, Lambert RK, Ionescu D, Woods R, Bai TR. Characterization of airway plugging in fatal asthma. Am J Med 2003; 115:6–11.

    Article  Google Scholar 

  6. Thompson HT, Pryor WJ, Hill J. Bronchial lavage in the treatment of obstructive lung disease. Thorax 1966; 21:557–559.

    Article  CAS  Google Scholar 

  7. Walker PE, Marshall M. Bronchial lavage in status asthmaticus. Br Med J 1969; 3:31–32.

    Article  CAS  Google Scholar 

  8. British Guideline on the Management of Asthma. British thoracic society Scottish intercollegiate guidelines network. Thorax 2008; 63:iv1–iv121.

    Article  Google Scholar 

  9. Brenner B, Corbridge T, Kazzi A. Intubation and mechanical ventilation of the asthmatic patient in respiratory failure. Proc Am Thorac Soc 2009; 6:371–379.

    Article  Google Scholar 

  10. Khan MF, Al Otair HA, Elgishy AF, Alzeer AH. Bronchoscopy as a rescue therapy in patients with status asthmaticus: two case reports and review of literature. Saudi J Anaesth 2013; 7:327–330.

    Article  Google Scholar 

  11. Maggi JC, Nussbaum E, Babbitt C, Maggi FE, Randhawa I. Pediatric fiberoptic bronchoscopy as adjunctive therapy in acute asthma with respiratory failure. Pediatr Pulmonol 2012; 47(12):1180–1184.

    Article  Google Scholar 

Download references

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Correspondence to Animesh Ray MBBS, MD(Med), DNB(Med), MNAMS, MRCP(UK), EDICI.

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Ray, A., Nangia, V., Chatterji, R. et al. Bronchoscopy as a salvage therapy in a mechanically ventilated status asthmaticus patient: A case report. Egypt J Bronchol 11, 66–69 (2017). https://doi.org/10.4103/1687-8426.198985

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  • DOI: https://doi.org/10.4103/1687-8426.198985

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