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Ethionamide-induced gynecomastia: A rare case report


Gynecomastia is a rare side effect of antitubercular chemotherapy. A 22-year-old male patient was diagnosed as a multidrug-resistant tuberculosis case and was put on standard second-line antituberculosis drugs. Two months later, the patient developed painful enlarged left breast with size 2×3cm2, mobile, tender, and normal nipple-areola without any discharge. Common endocrinological and biochemical tests were normal. Ethionamide-induced gynecomastia was suspected. Ultrasonography of the breast showed hypoechoic shadow suggesting glandular tissue hyperplasia without any deeper tissue infiltration. On discontinuing ethionamide, gynecomastia reduced gradually. On reintroduction, gynecomastia reappeared and again disappeared within weeks after withdrawal. Thus, painful gynecomastia induced by ethionamide was concluded. We report this case of unilateral painful gynecomastia because of its rarity and for the purpose of documentation and awareness.


  1. Braunstein GD. Gynecomastia. N Engl J Med 1993; 328:490–495.

    Article  CAS  Google Scholar 

  2. Thomson DF, Carter JR. Drug-induced gynecomastia. Pharmacotherapy 1993; 13:37–45.

    Google Scholar 

  3. Carlson HE. Gynecomastia. N Engl J Med 1980; 303:795–799.

    Article  CAS  Google Scholar 

  4. Petri WA Jr. Chemotherapy of tuberculosis, mycobacterium avium complex disease and leprosy. In: Brunton LL, Lazo JS, Parker KL, editors. Goodman and Gilmans the pharmacological basis of therapeutics. New York: Mc Graw-Hill; 2006. 1203–1224.

    Google Scholar 

  5. Braunstein GD. Aromatase and gynecomastia. Endocr Relat Cancer 1999; 6:315–324.

    Article  CAS  Google Scholar 

  6. Bembo SA, Carlson HE. Gynecomastia: its features, and when and how to treat it. Cleve Clin J Med 2004 71:511–517.

    Article  Google Scholar 

  7. Guinet P, Garin JP, Morpex A. A case of gynecomastia in pulmonary tuberculosis during the course of treatment with isonicotinic acid hydrazide. Lyon Med 1953; 85:281–284.

    Google Scholar 

  8. Chunhaswasdikul B. Gynecomastia in association with administration of thiacetazone in the treatment of tuberculosis. J Med Assoc Thai 1974; 57:323–327.

    CAS  PubMed  Google Scholar 

  9. Gumbo T. Chemotherapy of tuberculosis, Mycobacterium avium complex disease, and leprosy. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilmans the pharmacological basis of therapeutics. 12th ed. New Delhi: McGraw Hill; 2011. 1549–1570.

    Google Scholar 

  10. Carlson HE. Gynecomastia. In: Morley JE, Korenman SG, editors. Endocrinology and metabolism in the elderly. Boston: Blackwell Scientific Publications Inc; 1992. 294–307.

    Google Scholar 

  11. Bannayan GA, Hajdu SI. Gynecomastia: clinicopathologic study of 351 cases. Am J Clin Pathol 1972; 57:431–437.

    Article  CAS  Google Scholar 

  12. Fruhstorfer BH, Malata CM. A systematic approach to the surgical treatment of gynaecomastia. Br J Plastic Surg 2003; 56:237–246.

    Article  CAS  Google Scholar 

  13. Sharma PK, Bansal R. Gynecomastia caused by ethionamide. Indian J Pharmacol 2012; 44:654–655.

    Article  Google Scholar 

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Correspondence to Rupam K. Ta MBBS, MD (TB & RD), DNB.

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Banerjee, S.N., Ta, R.K., Mallick, M.S. et al. Ethionamide-induced gynecomastia: A rare case report. Egypt J Bronchol 11, 70–73 (2017).

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