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The Egyptian Journal of Bronchology
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Pattern of antiendothelial cell antibodies in patients with chronic obstructive pulmonary disease

Egyptian Journal of Bronchology volume 11, pages 203–208 (2017)Cite this article

Abstract

Background

Autoimmune mechanisms have been recently recognized as being partly involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Circulating autoantibodies have been detected in patients with COPD.

Objectives

The aim of this study was to estimate the level of antiendothelial cell antibodies (AECA) in COPD patients in the various GOLD stages.

Patients and methods

A comparative study assessed the level of AECA in three groups. COPD patients without cor pulmonale (18), with cor pulmonale (12), and the control group (10), from Beni-Suef University Hospital. Each group underwent background questionnaires and BMI measures. Enzyme-linked immunosorbent assay was used to measure the level of AECA in serum (ng/ml). Right ventricular systolic pressure (mm Hg) was measured in COPD patients with cor pulmonale.

Results

The studied groups consisted of male patients (age: 50–80 years). BMI was significantly lower (20.36) in the COPD group with cor pulmonale. Spirometry forced expiratory volume and forced expiratory volume/forced vital capacity ratios showed significantly lower levels among the COPD patients without cor pulmonale. AECA showed a lower level in the control group (26.25) compared with the COPD without cor pulmonale (57.87) and much lowered when compared to cor pulmonale group (71.47). The level of AECD was higher in the patients in third (74.78) and fourth stages (79.10) compared with those in the second stage (58.75).

Conclusion

There is a much higher level of AECA in COPD patients with cor pulmonale and in advanced stages in comparison with patients without cor pulmonale and at early stages, and a significant positive correlation was found between AECA levels and right ventricular systolic pressure.

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Authors and Affiliations

  1. Department of Chest, Faculty of Medicine, Beni-Sueif University, Egypt

    Randa Salah Eldin Mohamed

  2. Department of Chest Diseases and Tuberculosis, Chest Department Faculty of Medicine, Beni-Sueif University, Elfayoum Sheik Hamza Street Elhadka in front of Mekka Hospital, Egypt

    Mahmoud Mohamed Elbatanony & Abeer Salah Eldin Mohamed MD

  3. Suez Canal Institute, Egypt

    Sherif Elhadary (Doctor)

Authors
  1. Randa Salah Eldin Mohamed
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  2. Mahmoud Mohamed Elbatanony
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  3. Abeer Salah Eldin Mohamed MD
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  4. Sherif Elhadary
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Corresponding author

Correspondence to Abeer Salah Eldin Mohamed MD.

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Mohamed, R.S.E., Elbatanony, M.M., Mohamed, A.S.E. et al. Pattern of antiendothelial cell antibodies in patients with chronic obstructive pulmonary disease. Egypt J Bronchol 11, 203–208 (2017). https://doi.org/10.4103/1687-8426.203801

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  • DOI: https://doi.org/10.4103/1687-8426.203801

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