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The Egyptian Journal of Bronchology
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Evaluation of rapid pleurodesis technique in patients with malignant pleural effusion

Egyptian Journal of Bronchology volume 13, pages 377–381 (2019)Cite this article

Abstract

Background

The objective of this study is to see whether a rapid method of pleurodesis is superior to the standard protocol in patients with symptomatic malignant pleural effusion.

Patients and methods

This is a prospective, randomized control study that was held in Ain-Shams University Hospitals and included 30 patients diagnosed with malignant pleural effusion. Thirty patients who had been diagnosed with malignant pleural effusion histologically and/or cytologically were assessed and they were divided into two groups. Group A: 10 patients submitted to the standard pleurodesis technique using 24 or 28 F thoracotomy tube. Group B: 20 patients submitted to the rapid pleurodesis technique using pigtail (12 F). Pleurodesis was done by vibramycin and follow up of the patients was done with chest radiography at 1, 3, and 6 months after pleurodesis.

Results

There was no statistically significant difference in the demographic features, site of the primary tumor, disease characteristics, and response rates in any evaluation period in both groups. However, the number of days of drainage and hospitalization were significantly lower in the second group.

Conclusion

This new pleurodesis method provided a shorter hospital stay resulting in superior cost-effectiveness and palliation without sacrificing the efficacy of pleurodesis.

References

  1. Belani CP, Pajeau TS, Bennett CL. Treating malignant pleural effusions cost consciously. Chest 1998; 113:78S–85S.

    Article  CAS  Google Scholar 

  2. Antony VB, Loddenkemper R, Astoul P, Boutin C, Goldstraw P, Hott J, et al. Management of malignant pleural effusions. Eur Respir J 2001; 18:402–4198.

    Article  CAS  Google Scholar 

  3. Putnam JB Jr. Malignant pleural effusions. Surf Clin North Am 2002; 82:867–883.

    Article  Google Scholar 

  4. Antunes G, Neville E, Duffy J, Ali N. BTS guidelines for the management of malignant pleural effusions. Thorax 2003; 58 (Suppl. 2):ii29–ii38.

    Article  Google Scholar 

  5. Shields TW, locicero J, Reed CE, Feins RH. (Eds.) Malignant pleural effusion. General thoracic surgery. 7th ed. Philadelphia, PA:Lippincott Williams & Wilkins; 2009. 875–883

    Google Scholar 

  6. Rodriguez-Panadero F, Antony VB. Pleurodesis:state of the art. Eur Respir J 1997; 10:1648–1654.

    Article  CAS  Google Scholar 

  7. Heffner JE, LyleUnruh BS, Standerfer J, Torstveit J. Clinical efficacy of doxycycline for pleurodesis. Chest J 1994; 105:1743–1747.

    Article  CAS  Google Scholar 

  8. Putnam JB, Walsh GL, Swisher SG, Roth JA, Suell DM, Vaporciyan AA, et al. Outpatient management of malignant pleural effusion by a chronic indwelling pleural catheter. Ann Thorac Surg 2000; 69:369–375.

    Article  Google Scholar 

  9. Villanueva AG, Gray AW, Shahian DM, Williamson WA, Beamis JF Jr. Efficacy of short term versus long term tube thoracostomy drainage before tetracycline pleurodesis in the treatment of malignant pleural. Thorax 1994; 49:23–25.

    Article  CAS  Google Scholar 

  10. Patz EF Jr, McAdams HP, Goodman PC, Blackwell S, Crawford J. Ambulatory sclerotherapy for malignant pleural effusions. Radiology 1996; 199:133–135.

    Article  Google Scholar 

  11. Hsu WH, Chiang CD, Chen CY, Kwan PC, Hsu JY. Ultrasound-guided small-bore Elecath tube insertion for the rapid sclerotherapy of malignant pleural effusion. Jpn J Clin oncol 1998; 28: 187–189.

    Article  CAS  Google Scholar 

  12. Marom EM, Patz EF Jr, Erasmus JJ, McAdams HP, Goodman PC, Herndon JE. Malignant pleural effusions:treatment with small borecatheter thoracostomy and talc pleurodesis. Radiology 1999; 210:277–281.

    Article  CAS  Google Scholar 

  13. Yildirim E, Dural K, Yazkan R, Zengin N, Yildirim D, Gunal N, Sakinci U. Rapid pleurodesis in symptomatic malignant pleural effusion. Eur J Cardiothorac Surg 2005; 27:19–22.

    Article  Google Scholar 

  14. Spiegler PA, Hurewitz AN, Groth ML. Rapid pleurodesis for malignant pleural effusions. Chest 2003; 123:1895–1898.

    Article  Google Scholar 

  15. Porcel JM, Salud A, Nabal M, Vives M, Esquerda A, Rodríguez-Panadero F. Rapid pleurodesis with doxycycline through a small-bore catheter for the treatment of metastatic malignant effusions. Support Care Cancer 2006; 14:475.

    Article  Google Scholar 

  16. Bediwy AS, Amer HG. Pigtail catheter use for draining pleural effusions of various etiologies. ISRN Pulmonol 2012; 2012:143295.

    Article  Google Scholar 

  17. Musani AI, Haas AR, Seijo L, Wilby M, Sterman DH. Outpatient management of malignant pleural effusions with small-bore, tunneled pleural catheters. Respiration 2004; 71:559–566.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Chest Diseases, Pulmonology and Respiratory Intensive Care Unit, Faculty of medicine, Ain Shams University, 11815, Cairo, Egypt

    Muhammed A. Farrag, Haytham S. Diab MD (Assistant Professor) & Muhammed R. Abd Al Aziz Taha

Authors
  1. Muhammed A. Farrag
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  2. Haytham S. Diab MD
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  3. Muhammed R. Abd Al Aziz Taha
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Corresponding author

Correspondence to Haytham S. Diab MD.

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Farrag, M.A., Diab, H.S. & Abd Al Aziz Taha, M.R. Evaluation of rapid pleurodesis technique in patients with malignant pleural effusion. Egypt J Bronchol 13, 377–381 (2019). https://doi.org/10.4103/ejb.ejb_102_17

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  • DOI: https://doi.org/10.4103/ejb.ejb_102_17

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