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Predictors of failure of early shift from invasive to noninvasive ventilation in weaning chronic obstructive pulmonary disease patients who have failed the initial spontaneous breathing trial: a prospective cohort study

Egyptian Journal of Bronchology volume 12, pages 49–56 (2018)Cite this article

Abstract

Context

Noninvasive ventilation (NIV) is a well-established modality for difficult and prolonged weaning of chronic obstructive pulmonary disease (COPD) patients. Although several studies have addressed the early shifting to NIV, predictors of its success remain to be determined.

Aims

The aim of the study was to find predictors of success of early shift of COPD patients who have failed the spontaneous breathing trail (SBT) to NIV.

Design and settings

This investigation was designed as a double-centered prospective cohort study involving the ICUs of Critical Care Medicine of Cairo University and Shebin El-Kom Teaching Hospital.

Patients and methods

Consecutive COPD patients who failed the initial SBT were extubated and shifted to NIV. We compared arterial blood gases, lung mechanics, and spontaneous breathing parameters in successful patients with these parameters in those who failed the early shift to NIV.

Results

Out of the 30 patients, 21 (70%) were successfully weaned by early shift to NIV. The failed group had a significantly higher autopositive end-expiratory pressure (P<0.001), rapid shallow breathing index (RSBI) (P<0.05), and significantly lower static compliance and negative inspiratory pressure (NIP) (P<0.001) on admission.

Admission RSBI and NIP were the only predictors of failure of early shift to NIV. Just before SBT, the failed group had a significantly higher autopositive end-expiratory pressure (P<0.001), RSBI (P<0.001), and airway resistance (Raw) (P<0.001) and significantly lower static compliance, NIP, and PO2/FIO2 (P/F) ratio. Raw and NIP before SBT were the only predictors of success of early shift to NIV.

Conclusion

RSBI, NIP, and Raw, rather than arterial blood gases, are the most important predictors for success of early shift to NIV in COPD patients who have failed the initial SBT.

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Authors and Affiliations

  1. Shebin El-Kom Educational University, Al Minufiyah, Egypt

    Sameh A. Moneim

  2. Department of Critical Care Medicine, Cairo University, Giza, 11211, Egypt

    Tamer S. Fahmy MD, PhD & Nashwa Abed

Authors
  1. Sameh A. Moneim
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  2. Tamer S. Fahmy MD, PhD
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  3. Nashwa Abed
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Corresponding author

Correspondence to Tamer S. Fahmy MD, PhD.

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Moneim, S.A., Fahmy, T.S. & Abed, N. Predictors of failure of early shift from invasive to noninvasive ventilation in weaning chronic obstructive pulmonary disease patients who have failed the initial spontaneous breathing trial: a prospective cohort study. Egypt J Bronchol 12, 49–56 (2018). https://doi.org/10.4103/ejb.ejb_11_17

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  • DOI: https://doi.org/10.4103/ejb.ejb_11_17

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