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The Egyptian Journal of Bronchology
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Magnetic resonance spectroscopy in evaluating cerebral metabolite imbalance in chronic obstructive pulmonary disease

Egyptian Journal of Bronchology volume 12, pages 14–19 (2018)Cite this article

Abstract

Rationale

Magnetic resonance spectroscopy (MRS) is a powerful research tool and has been proved to provide additional clinically relevant information for several diseases such as brain tumors, metabolic disorders, and systemic diseases.

Aim

The aims of this study were to evaluate cerebral metabolic imbalance in chronic obstructive pulmonary disease (COPD) and to correlate the abnormalities with spirometric and gasometric parameters.

Patients and methods

In a case–control study, eight COPD patients and eight age-matched and sex-matched healthy control individuals were compared. 1H-MRS was performed using 1.5-T MRI/MRS scanner. Using 1H-MRS single-voxel technique, N-acetyl aspartate/choline (NAA/Cho), choline/ creatine (Cho/Cr), and N-acetyl aspartate/creatine (NAA/Cr) ratios were estimated and compared in both groups.

Results

There were significant differences regarding the distribution of neurotransmitters in the temporal lobe only between COPD and control groups; there were significant positive correlations between the NAA/Cho ratio at the thalamus with both partial pressure of arterial carbon dioxide and base excess or base deficit. However, there was a significant positive correlation between the Cho/Cr ratio at the thalamus and forced vital capacity (l), and a significant positive correlation between the NAA/Cr ratio at the thalamus andBMI, and a negative correlation between the NAA/Cr ratio at the thalamus and partial pressure of arterial oxygen. There was a significant negative correlation between theNAA/Cr ratio at the temporal lobe and partial pressure of arterial carbon dioxide.

Conclusion

MRS provided an insight to study the neurochemical changes that occur in COPD patients. Chronic hypoxemia and hypercapnia seem to play a key role in the pathophysiology of neurochemical changes in COPD.

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Author information

Authors and Affiliations

  1. Department of Chest Diseases and Tuberculosis, Faculty of Medicine, Assuit University, Assuit, 71515, Egypt

    Olfat M. El-Shinnawy, Mohamed M. Metwally, Alaa EL-din Thabiet Hassan & Ahmad M. Shaddad MSc

  2. Neurology and Psychiatry and Diagnostic Radiology Departments, Faculty of Medicine, Assuit University, Assuit, Egypt

    Eman M. Khedr

  3. Diagnostic Radiology Departments, Faculty of Medicine, Assuit University, Assuit, Egypt

    Radwa Kamel Soliman

Authors
  1. Olfat M. El-Shinnawy
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  2. Eman M. Khedr
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  3. Mohamed M. Metwally
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  4. Alaa EL-din Thabiet Hassan
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  5. Ahmad M. Shaddad MSc
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  6. Radwa Kamel Soliman
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Corresponding author

Correspondence to Ahmad M. Shaddad MSc.

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El-Shinnawy, O.M., Khedr, E.M., Metwally, M.M. et al. Magnetic resonance spectroscopy in evaluating cerebral metabolite imbalance in chronic obstructive pulmonary disease. Egypt J Bronchol 12, 14–19 (2018). https://doi.org/10.4103/ejb.ejb_28_17

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  • DOI: https://doi.org/10.4103/ejb.ejb_28_17

Key words

  • cerebral bioenergetics in chronic obstructive pulmonary disease
  • cerebral metabolite imbalance in chronic obstructive pulmonary disease
  • magnetic resonance spectroscopy in chronic obstructive pulmonary disease