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Comparison between cryobiopsy and forceps biopsy in detection of epidermal growth factor receptor amplification in non-small-cell lung cancer

Egyptian Journal of Bronchology volume 13, pages 636–643 (2019)Cite this article

Abstract

Background

Non-small-cell lung cancer (NSCLC) represents 85% of lung cancer cases. Genotyping is now considered as a cornerstone in proper management and better results of such cancers, especially with targeted therapy. Cryobiopsy is a promising tool in NSCLC to obtain larger samples, with well-preserved tissue sufficient for accurate histopathological and gene detection.

Aim

To compare cryobiopsy and ordinary forceps results in detection of epidermal growth factor receptor (EGFR) amplification in NSCLC.

Materials and methods

Samples from 34 patients with proven NSCLC by cryobiopsy versus forceps biopsy were compared for size, quality, and diagnostic yield of EGFR gene amplification.

Results

The samples obtained by cryoprobe had larger size and better artifact-free areas with more diagnostic yield of EGFR gene amplification (29.4%) versus with forceps biopsy (8.8%), with gene amplification showing higher statistical significance in younger patients, never smokers, and women (P<0.001).

Conclusion

Cryobiopsy is an excellent tool for larger, better-quality sampling and for higher diagnostic yield of EGFR amplification in NSCLC.

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Author information

Authors and Affiliations

  1. Department of Chest, Faculty of Medicine, Tanta University, Tanta, 1221, Egypt

    Ahmed S. H. Mohamed, Mohamed Hantera & Ragia S. Sharshar MD

  2. Department of Clinical Pathology, Tanta University, Tanta, Egypt

    Amira Y. Abdelnaby

  3. Department of Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt

    Ayman El Saka

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  1. Ahmed S. H. Mohamed
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  2. Mohamed Hantera
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  3. Ragia S. Sharshar MD
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  4. Amira Y. Abdelnaby
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  5. Ayman El Saka
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Correspondence to Ragia S. Sharshar MD.

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Mohamed, A.S.H., Hantera, M., Sharshar, R.S. et al. Comparison between cryobiopsy and forceps biopsy in detection of epidermal growth factor receptor amplification in non-small-cell lung cancer. Egypt J Bronchol 13, 636–643 (2019). https://doi.org/10.4103/ejb.ejb_40_19

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  • DOI: https://doi.org/10.4103/ejb.ejb_40_19

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