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The Egyptian Journal of Bronchology
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Does vitamin D deficiency worsen the clinical and functional parameters of stable chronic obstructive pulmonary disease patients?

Egyptian Journal of Bronchology volume 13, pages 584–590 (2019)Cite this article

Abstract

Introduction

There is not much data about the effect of deficient vitamin D on stable chronic obstructive pulmonary disease (COPD) patients and its relation to the disease severity.

Objective

The aim was to measure the serum level of 25-hydroxy (OH) vitamin D in stable COPD patients, and to assess its relation to COPD severity and functional parameters.

Patients and methods

A prospective study that was carried out at Chest Department, Kasr El-Aini Hospital, Cairo University. It was carried out on 70 male individuals: 50 stable COPD patients and 20 healthy individuals. All persons were subjected to history taking, clinical examination, 6 min walk test (6MWT), spirometry, and measurement of 25(OH) vitamin D serum level.

Results

Our results showed a deficiency of vitamin D in 37 (74%) of the COPD patients. It showed a significant lower level of 25(OH) vitamin D in COPD cases who were severe and very severe, compared with those who were mild and moderate ones (P=0.017). There was also a positive significant correlation between vitamin D level and 6 min walk distance, basal oxygen saturation, post-6MWT oxygen saturation, and forced expiratory volume in the first second predicted, and an inverse correlation with basal heart rate and post-6MWT heart rate.

Conclusion

The study highlights the value of measurement of vitamin D level in COPD, as a potential therapeutic agent. Vitamin D serum level showed low values in COPD cases compared with healthy ones and was correlated significantly to forced expiratory volume in the first second predicted.

References

  1. Prosser DE, Jones G. Enzymes involved in the activation and inactivation of vitamin D. Trends Biochem Sci 2004; 29:664–673.

    Article  CAS  Google Scholar 

  2. Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357:266–281.

    Article  CAS  Google Scholar 

  3. Janssens W, Bouillon R, Claes B, Carremans C, Lehouck A, Buysschaert I, et al. Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene. Thorax 2010; 65:215–220.

    Article  Google Scholar 

  4. Zasloff M. Fighting infections with vitamin D. Nat Med 2006; 12:388–390.

    Article  CAS  Google Scholar 

  5. Menant JC, Close JC, Delbaere K, Sturnieks DL, Trollor J, Sachdev PS, et al. Relationships between serum vitamin D levels, neuromuscular and neuropsychological function and falls in older men and women. Osteoporos Int 2012; 23:981–989.

    Article  CAS  Google Scholar 

  6. This Executive Summary of the Global Stragegy for the Diagnosis, Management, and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD). 2017.

  7. Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry. Eur Respir J 2005; 26:319–338.

    Article  CAS  Google Scholar 

  8. ATS Statement. Guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002; 166:111–117.

    Article  Google Scholar 

  9. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 2008; 87:1080–1086.

    Article  Google Scholar 

  10. Said AF, Abd-Elnaeem EA. Vitamin D and chronic obstructive pulmonary disease. Egypt J Chest Dis Tuberc 2015; 64:67–73.

    Article  Google Scholar 

  11. Chan YH. Biostatistics 102: quantitative data – parametric & non-parametric tests. Singapore Med J 2003a; 44:391–396.

    CAS  PubMed  Google Scholar 

  12. Chan YH. Biostatistics 103: qualitative data -tests of independence. Singapore Med J 2003b; 44:498–503.

    CAS  PubMed  Google Scholar 

  13. Chan YH. Biostatistics 104: correlational analysis. Singapore Med J 2003c; 44:614–619.

    CAS  PubMed  Google Scholar 

  14. Franco CB, Paz-Filho G, Gomes PE, Nascimento VB, Kulak CA, Boguszewski CL, et al. Chronic obstructive pulmonary disease is associated with osteoporosis and low levels of vitamin D. Osteoporos Int 2009; 20:1881–1887.

    Article  CAS  Google Scholar 

  15. Hughes DA, Norton R. Vitamin D and respiratory health. Clin Exp Immunol 2009; 158:20–25.

    Article  CAS  Google Scholar 

  16. Berg I, Hanson C, Sayles H, Romberger D, Nelson A, Meza J, et al. Vitamin D, vitamin D binding protein, lung function and structure in COPD. Respiratory medicine 2013; 107:1578–1588.

    Article  Google Scholar 

  17. Persson LJP, Aanerud M, Hiemstra PS, Hardie JA, Bakke PS, Eagan TML. Chronic obstructive pulmonary disease is associated with low levels of vitamin D. PLoS One 2012; 7:e38934.

    Article  CAS  Google Scholar 

  18. Diaz A, Bourassa MG, Guertin MC, Tardif JC. Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease. Eur Heart J 2005; 26:967–974.

    Article  Google Scholar 

  19. Jensen MT, Marott JL, Jensen GB. Elevated resting heart rate is associated with greater risk of cardiovascular and all-cause mortality in current and former smokers. Int J Cardiol 2011; 151:148–154.

    Article  Google Scholar 

  20. Jensen MT, Marott JL, Lange P, Vestbo J, Schnohr P, Nielsen OW, et al. Resting heart rate is a predictor of mortality in chronic obstructive pulmonary disease. Eur Respir J [Internet] 2013; 42:341–349. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23143550

    Article  Google Scholar 

  21. El-Shafey BI, El-Srougy HA. Does serum 25 hydroxy vitamin D level play a role in COPD? Egypt J Tuberc Lung Dis 2014; 63:43–47.

    Article  Google Scholar 

  22. Zhu M, Wang T, Wang C, Ji Y. The association between vitamin D and COPD risk, severity, and exacerbation: an updated systematic review and meta-analysis. Int J Chron Obstruct Pulmon Dis 2016; 11:2597–2607.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Chest Diseases, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt

    Esmat A. Abd Elnaby, Samah S. Abd Elnaiem, Amira I. Mostafa MD & Mohamed K. Haswa

  2. Department of Biochemistry, Faculty of Medicine, Cairo University Hospital, Cairo, Egypt

    Dina Sabry

Authors
  1. Esmat A. Abd Elnaby
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  2. Samah S. Abd Elnaiem
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  3. Amira I. Mostafa MD
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  4. Dina Sabry
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  5. Mohamed K. Haswa
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Corresponding author

Correspondence to Amira I. Mostafa MD.

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Abd Elnaby, E.A., Abd Elnaiem, S.S., Mostafa, A.I. et al. Does vitamin D deficiency worsen the clinical and functional parameters of stable chronic obstructive pulmonary disease patients?. Egypt J Bronchol 13, 584–590 (2019). https://doi.org/10.4103/ejb.ejb_44_19

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  • DOI: https://doi.org/10.4103/ejb.ejb_44_19

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