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Metabolic syndrome; frequency and its relationship with variable parameters in chronic obstructive pulmonary disease
Egyptian Journal of Bronchology volume 13, pages 148–154 (2019)
Abstract
Background
Chronic obstructive pulmonary disease (COPD) has many extrapulmonary comorbidities, and metabolic syndrome (MetS) is one of them. Scant data are available on MetS in Egyptian patients with COPD.
Objective
The purpose of the current research was to determine the frequency and clinical characteristics of MetS among Egyptian patients with stable COPD.
Patients and methods
A prospective study including 70 (64 males and six females) patients with stable COPD was conducted. Clinical assessment, pulmonary function, and other laboratory studies were performed.
Results
MetS was present in 31 patients with COPD (44.3%). BMI and high-sensitivity C-reactive protein were significantly higher in patients with COPD with MetS than those without MetS (P=0.02 and 0.01, respectively). Age of the patients, duration of COPD, grade of dyspnea, and pulmonary function tests had no significant difference between those with MetS versus those without it.
There was a significant negative correlation between plasma triglyceride level, as the only one of the variables of MetS, and some of parameters of pulmonary function test.
Conclusion
MetS is relatively frequent among patients with COPD. Plasma triglyceride level is the only parameter of MetS to have a significant correlation with pulmonary function tests. Apart from BMI and high-sensitivity C-reactive protein, no other parameter among patients with COPD has a significant relationship with MetS.
References
Cameron AJ, Shaw JE, Zimmet PZ. The metabolic syndrome:prevalence in worldwide populations. Endocrinol Metab Clin North Am 2004; 33:351–375.
National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult treatment panel III) final report. Circulation 2002; 106:3143–3421.
Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, et al. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease:GOLD executive summary. Am J Respir Crit Care Med 2007; 176:532–555.
Sin DD, Anthonisen NR, Soriano JB, Agusti AG. Mortality in COPD:role of comorbidities. Eur Respir J 2006; 28:1245–1257.
Agusti A. Systemic effects of chronic obstructive pulmonary disease:what we know and what we don’t know (but should). Proc Am Thorac Soc 2007; 4:522–525.
Fabbri LM, Rabe KF. From COPD to chronic systemic inflammatory syndrome? Lancet 2007; 370:797–799.
Marquis K, Maltais F, Duguay V, Bezeau AM, LeBlanc P, Jobin J, et al. Metabolic syndrome in patients with chronic obstructive pulmonary disease. J Cardiopulm Rehabil 2005; 25:226–232.
Global Initiative for Chronic Obstructive Lung Disease (GOLD), (2016); Global strategy for the diagnosis, management, and prevention of COPD. Available at:http://www.goldcopd.org. [Accessed date 2016]
Harik-khan RI, Fleg JI, Wise RA. Body mass index & risk of COPD. Chest 2002; 121:370–376.
WHO. WHO STEP wise approach to surveillance (STEPS). Geneva:World Health Organization (WHO); 2008.
Baffi CW, Wood L, Winnica D, Strollo PJ, Gladwin MT, Que LG, et al. Metabolic syndrome and the lung. Chest 2016; 149:1525–1534.
Funakoshi Y, Omori H, Mihara S, Katoh T. Association between airflow obstruction and the metabolic syndrome and its components in Japanese men. Intern Med 2010; 49:2093–2099.
Acharrya A, Shahjahan MD, Mesbah FB, Dey SK, Ali L. Association of metabolic syndrome with chronic obstructive pulmonary disease in an Indian population. Lung India 2016; 33:385–390.
Ghatas T. The relationship between metabolic syndrome and chronic obstructive pulmonary disease. Egypt J Bronchol 2017; 11:11–15.
World Health Organization: Definition, Diagnosis and Classification of Diabetes Mellitusand its Complications:Report of a WHO Consultation. Part 1:diagnosis and classificationof diabetes mellitus. Geneva:World Health Organization 1999.
Díez-Manglano J, Barquero-Romero J, Almagro P, Cabrera FJ, López García F, Montero L, et al. Working Group on COPD, Spanish Society of Internal Medicine. COPD patients with and without metabolic syndrome:clinical and functional differences. Intern Emerg Med 2014; 9:419–425.
Breyer MK, Spruit MA, Hanson CK, Franssen FM, Vanfleteren LE, Groenen MT, et al. Prevalence of metabolic syndrome in COPD patients and its consequences. PLoS One 2014; 9:e98013.
Dahl M, Vestbo J, Lange P, Bojesen SE, Tybjaerg-Hansen A, Nordestgaard BG. C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007; 175:250–255.
Stanciu S, Marinescu R, Iordache M, Dumitrescu S, Mureşan M, Boğdan MA. Are systemic inflammatory profiles different in patients with COPD and metabolic syndrome as compared to those with COPD alone? Rom J Intern Med 2009; 47:381–386.
Akpinar EE, Akpinar S, Ertek S, Sayın E, Gulhan M. Systemic inflammation and metabolic syndrome in stable COPD patients. Tuberk Toraks 2012; 60:230–237.
Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006; 444:860–867.
Alpaydin AO, Arslan IK, Serter S, Coskun AS, Celik P, Taneli F, Yorganciogl A. Metabolic syndrome and carotid intima-media thickness in chronic obstructive pulmonary disease. Multidiscip Respir Med 2013; 8:61.
Ameen NM, Mohamed RS, Abd EI Mageed NI. The metabolic syndrome in patients with chronic obstructive pulmonary disease. Egypt J Chest Dis Tuberc 2016; 65:593–596.
Popović-Grle S, Ladić A, Butorac-Petanjek B, Špiček-Macan J, Čucević B. Waist circumference does not correlate with functional lung capac ity in moderate and severe chronic obstructive pulmonary disease. Acta Clin Croat 2013; 52:69–77.
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El-toney, A.F.S., Mohamed, B.I., Abd-Elnaeem, E.A. et al. Metabolic syndrome; frequency and its relationship with variable parameters in chronic obstructive pulmonary disease. Egypt J Bronchol 13, 148–154 (2019). https://doi.org/10.4103/ejb.ejb_51_18
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DOI: https://doi.org/10.4103/ejb.ejb_51_18