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The prevalence of Helicobacter Pylori infection in patients with obstructive sleep apnea having metabolic syndrome and its relation to both disorders

Egyptian Journal of Bronchology volume 11, pages 268–275 (2017)Cite this article

Abstract

Introduction

Obstructive sleep apnea hypopnea syndrome (OSAHS) is a highly prevalent respiratory disorder and is associated with metabolic syndrome (MS). Helicobacter pylori (H. pylori) infection (Hp-I)maybe involved in the pathogenesis of both obstructive sleep apnea (OSA) and gastroesophageal reflux disease(GERD);the latter is alsoassociatedwithOSAHS. Anassociation betweenHp-IandOSAhas beenreportedas well as a potential association between Hp-I and insulin resistance, which represents the pathogenetic basis of MS.

Objective

To study the prevalence of Hp-I in patients with OSAHS having MS and its relation to both OSAHS and MS and to asses GERD symptoms in the studied groups and its relation to the severity of OSA and to Hp-I.

Patients and methods

This study included 28 patients with confirmed OSAHS by overnight polysomnography, with half of them having MS. Demographic, comorbidities, anthropometric, and clinical data were collected. Stool analysis for H. pylori antigen was done.

Results

Patients with OSAHS with MS had significantly more severe OSA (P≤0.001*). The prevalence of both Hp-I and GERD was significantly higher in the MS group (P=0.023 and 0.018, respectively). GERD was significantly associated with H. pylori infection in the studied groups (P<0.001). The prevalence of Hp-I and GERD increased with the severity of OSAHS, but it did not reach statistical significance, as in patients with mild, moderate, and severe OSAHS, the prevalence of Hp-I and GERD was 16.7, 50, and 64.3%, respectively, and 12.5, 25, and 62.5%, respectively.

Conclusion

H. pylori infection can be considered as a potential confounder involved in OSAHS and GERD pathophysiology associated with MS. Egypt J Bronchol 2017 11:268–275

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Authors and Affiliations

  1. Department of Chest Diseases, Faculty of Medicine, Alexandria University, Alexandria, 21524, Egypt

    Laila A. H. Banawan & Rasha G. A. Daabis MD

  2. Internal Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt

    Wafaa H. Elsheikh

  3. Department of Parasitology, Medicine Research Institute, Alexandria University, Alexandria, Egypt

    Mona M. Tolba

  4. Department of Chest Diseases, Shobrakhit Central Hospital, Alexandria, Egypt

    Amira M. Youssef

Authors
  1. Laila A. H. Banawan
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  2. Rasha G. A. Daabis MD
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  3. Wafaa H. Elsheikh
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  4. Mona M. Tolba
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  5. Amira M. Youssef
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Correspondence to Rasha G. A. Daabis MD.

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Banawan, L.A.H., Daabis, R.G.A., Elsheikh, W.H. et al. The prevalence of Helicobacter Pylori infection in patients with obstructive sleep apnea having metabolic syndrome and its relation to both disorders. Egypt J Bronchol 11, 268–275 (2017). https://doi.org/10.4103/ejb.ejb_54_16

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