Skip to main content
The Egyptian Journal of Bronchology
Download PDF
  • Original article
  • Open access
  • Published:

Medication adherence and treatment satisfaction in some Egyptian patients with chronic obstructive pulmonary disease and bronchial asthma

Egyptian Journal of Bronchology volume 12, pages 33–40 (2018)Cite this article

Abstract

Background

The degree of effectiveness in the management of asthma and chronic obstructive pulmonary disease (COPD) entails proper treatment adherence and satisfaction. In this study, medication adherence and treatment satisfaction were assessed among some Egyptian patients with asthma and COPD.

Materials and methods

Consecutive asthma and COPD patients were recruited from the outpatient clinic or inpatients admitted to the Chest Department at Ain Shams University Hospital, Abbassia, and Qena Chest Hospitals. Self-reported medication adherence and treatment satisfaction were tested using the Arabic versions of the eight-item Morisky Medication Adherence Scale and Treatment Satisfaction Questionnaire for Medication (TSQM 1.4), respectively.

Results

Totally, 474 asthmatic patients (mean: 34.41 years, 61.2% male and 38.8% female) and 509 COPD patients (mean: 60.39 years, 91.7% male and 8.3% female) were included. According to eight-item Morisky Medication Adherence Scale, mean adherence was 4.55±2.01 and 3.88 ±1.63 in asthma and COPD, respectively, with no significant difference. In asthma and COPD, low adherence was found in 71.7 and 79.4%, medium adherence in 19.8 and 13.6%, and high adherence in 8.4 and 7.1%, respectively. There was a significant difference in all domains of TSQM between asthma and COPD, with more effectiveness, convenience, and global satisfaction but less side effects among asthma patients compared with COPD. There was a significant correlation in asthmatic patients between adherence and all domains of TSQM, whereas in COPD only side effects and convenience correlated significantly with adherence. In COPD, adherence was better in male smokers, with low smoking index, living in urban areas, having severe small airway obstruction, and treated by pulmonologists. In asthma, adherence was mainly affected by treatment satisfaction.

Conclusion

Most of the asthma and COPD patients were nonadherent to their medications. Asthma patients were more satisfied with treatment compared with COPD patients.

References

  1. Osman L. The patient perspective. What should a new anti-asthma agent provide? Drugs 1996; 52:29–35.

    Article  PubMed  Google Scholar 

  2. Tabor PA, Lopez DA. Comply with us: improving medication adherence. J Pharm Pract 2004; 17:167–181.

    Article  Google Scholar 

  3. Osterberg L, Blaschke T. Drug therapy: adherence to medication. N Engl J Med 2005; 353:487–497.

    Article  CAS  PubMed  Google Scholar 

  4. Weaver M, Patrick DL, Markson LE, Martin D, Frederic I, Berger M. Issues in the measurement of satisfaction with treatment.Am J Manag Care 1997; 3:579–594.

  5. Global Initiative for Chronic Obstructive Lung Diseases. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. 2014. Available at: http://www.goldcopd.org. [Last accessed 2017 Jun 20].

  6. Global Initiative forAsthma (GINA). Global strategy for asthmamanagement and prevention. 2014. Available at: http://www.ginasthma.org. [Last accessed 2017 Jun 20].

  7. MillerMR,CrapoR,HankinsonJ,BrusascoV,BurgosF,CasaburiR, etal.ATS/ ERS Task Force: Standardisation of lung function testing. General considerations for lung function testing. Eur Respir J 2005; 26:153–161.

  8. Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence.MedCare 1986; 24:67–74.

    CAS  Google Scholar 

  9. Morisky DE, Ang A, Krousel-Wood M, Ward HJ. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens 2008; 10:348–354.

    Article  Google Scholar 

  10. Krousel-Wood MA, Islam T, Webber LS, Re RS, Morisky DE, Muntner P. New medication adherence scale versus pharmacy fill rates in seniors with hypertension. Am J Manag Care 2009; 15:59–66.

    PubMed  PubMed Central  Google Scholar 

  11. Morisky DE, DiMatteo MR. Improving the measurement of self-reported medication nonadherence: final response. JClin Epidemio 2011; 64:258–263.

    Article  Google Scholar 

  12. Bharmal M, Payne K, Atkinson MJ, Desrosiers MP, Morisky DE, Gemmen E. Validation of an abbreviated Treatment Satisfaction Questionnaire for Medication (TSQM-9) among patients on antihypertensive medications. Health Qual Life Outcomes 2009; 7:36.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Atkinson MJ, Sinha A, Hass SL, Colman SS, Kumar RN, Brod M, Rowland CR. Validation of a general measure of treatment satisfaction, the Treatment Satisfaction Questionnaire for Medication (TSQM), using a national panel studyof chronic disease.HealthQual LifeOutcomes2004;2:12.Available at: https://www.quintiles.com/TSQM/#sthash.4p9VbP2j.dpuf. [Last accessed 2017 Jun 20].

  14. Atkinson MJ, Kumar R, Cappelleri JC, Hass SL. Hierarchical construct validity of the treatment satisfaction questionnaire for medication (TSQM version II) among outpatient pharmacy consumers. Value Health 2005; 8 (Suppl 1):S9–S24.

  15. Bozek A, Jarzab J. Adherence to asthma therapy in elderly patients. J Asthma 2010; 47:162–165.

    Article  PubMed  Google Scholar 

  16. Latry P, Pinet M, Labat A, Magand JP, Peter C, Robinson P, et al. Adherence to anti-inflammatory treatment for asthma in clinical practice in France. Clin Ther 2008; 30:1058–1068.

    Article  PubMed  Google Scholar 

  17. Jones C, Santanello NC, Boccuzzi SJ, Wogen J, Strub P, Nelsen LM. Adherence to prescribed treatment for asthma: evidence from pharmacy benefits data. J Asthma 2003; 40:93–101.

    Article  PubMed  Google Scholar 

  18. Clerisme-Beaty EM, Bartlett SJ, Teague WG, Lima J, Irvin CG, Cohen R. The Madison avenue effect: how drug presentation style influences adherence and outcome in patients with asthma. J Allergy Clin Immunol 2011; 127:406–411.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Rand CS, Wise RA. Measuring adherence to asthma medication regimens. Am J Respir Crit Care Med 1994; 149:69–78.

    Article  Google Scholar 

  20. Rolnick SJ, Pawloski PA, Hedblom BD, Asche SE, Bruzek RJ. Patient characteristics associated with medication adherence. Clin Med Res 2013; 11:54–65.

    Article  PubMed  PubMed Central  Google Scholar 

  21. World Health Organization. Adherence to long-term therapies: policy for action. Meeting report. 4–5 June 2001. 2003. Available at: http://www.who.int/hiv/pub/prev_care/lttherapies/en/. [Last accessed 2017 Jun 20].

  22. Dolce JJ, Crisp C, Manzella B, Richards JM, Hardin JM, Bailey WC. Medication adherence patterns in chronic obstructive pulmonary disease. Chest 1991; 99:837–841.

    Article  CAS  PubMed  Google Scholar 

  23. Bender BG, Bender SE. Patient-identified barriers to asthma treatment adherence: responses to interviews, focus groups, and questionnaires. Immunol Allergy Clin North Am 2005; 25:107–130.

    Article  PubMed  Google Scholar 

  24. Lareau SC, Yawn BP. Improving adherence with inhaler therapy in COPD. Int J Chron Obstruct Pulmon Dis 2010; 5:401–406.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Madkour I, Galal I. Do Egyptian patients use their inhalers correctly? A checklist auditing for inhalation devices usage techniques. Egypt J Chest Dis Tuberc 2015; 64:497–504.

    Article  Google Scholar 

  26. Restrepo RD, Alvarez MT, Wittnebel LD, Sorenson H, Wettstein R, Vines DL, et al. Medication adherence issues in patients treated for COPD. Int J Chron Obstruct Pulmon Dis 2008; 3:371–384.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Lau HS, Beuning KS, Postma-Lim E, Klein-Beernink L, de Boer A, Porsius AJ. Non-compliance in elderly people: evaluation of risk factors by longitudinal data analysis. Pharm World Sci 1996; 18:63–68.

    Article  CAS  PubMed  Google Scholar 

  28. Laforest L, Denis F, van Ganse E, Ritleng C, Saussier C, Passante N, et al. Correlates of adherence to respiratory drugs in COPD patients. Prim Care Respir J 2010; 19:148–154.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Nici L, Donner C, Wouters E, Zuwallack R, Ambrosino N, Bourbeau J, et al. American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation. Am J Respir Crit Care Med 2006; 173: 1390–1413.

    Article  PubMed  Google Scholar 

  30. Ágh T, Inotai A, Mészáros Á. Factors associated with medication adherence in patients with chronic obstructive pulmonary disease. Respiration 2011; 82:328–334.

    Article  PubMed  Google Scholar 

  31. Tashkin DP. Multiple dose regimens. Impact on compliance. Chest 1995; 107:176S–182S.

    CAS  PubMed  Google Scholar 

  32. Morris LS, Schulz RM. Patient compliance – an overview. J Clin Pharm Ther 1992; 17:283–295.

    Article  CAS  PubMed  Google Scholar 

  33. Hughes CM. Medication non-adherence in the elderly: how big is the problem? Drugs Aging 2004; 21:793–811.

    Article  PubMed  Google Scholar 

  34. Cully JA, Graham DP, Stanley MA, Ferguson CJ, Sharafkhaneh A, Souchek J, et al. Quality of life in patients with chronic obstructive pulmonary disease and comorbid anxiety or depression. Psychosomatics 2006; 47:312–319.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chest Diseases, Ain Shams University, 4 Ibn Haggar Askalany Street, Heliopolis, Cairo, 11575, Egypt

    Iman H. Galal MD, PhD & Yasser M. Mohammad

  2. Department of Chest Diseases, Abbassia Chest Hospital, Cairo, Egypt

    Abeer A. Nada

  3. Qena Chest Hospital, Qena, Egypt

    Yosra E. Mohran

Authors
  1. Iman H. Galal MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yasser M. Mohammad
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Abeer A. Nada
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yosra E. Mohran
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Iman H. Galal MD, PhD.

Additional information

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work noncommercially, as long as the author is credited and the new creations are licensed under the identical terms.

Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Galal, I.H., Mohammad, Y.M., Nada, A.A. et al. Medication adherence and treatment satisfaction in some Egyptian patients with chronic obstructive pulmonary disease and bronchial asthma. Egypt J Bronchol 12, 33–40 (2018). https://doi.org/10.4103/ejb.ejb_56_17

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.4103/ejb.ejb_56_17

Key words