Skip to main content
The Egyptian Journal of Bronchology
Download PDF

Relationship between platelet count, platelet indices, and inflammatory markers in stable and acute exacerbation of bronchiectasis patients

Egyptian Journal of Bronchology volume 12, pages 173–179 (2018)Cite this article

Abstract

Background and objective

Persistent and chronic infection is one of the reasons underlying the sustained inflammation in bronchiectasis patients, and inflammatory markers may possess important clinical implications in the follow-up. Platelets are known to have effects on inflammatory response; in addition, a negative correlation has been shown between mean platelet volume (MPV) and inflammatory disease activity. The objective of this paper is to investigate and compare the levels of platelet (PLT) count and platelet indices during stable and acute exacerbation of bronchiectasis patients.

Patients and methods

Data were retrospectively collected from medical files of 63 patients (39 women) and 29 controls without bronchiectasis. Thirty patients had an acute exacerbation, and 33 were in a stable state of disease. Descriptive data, clinical, radiologic, and laboratory information were noted. The relationship between inflammatory markers and pulmonary function tests was evaluated.

Results

White blood cell (WBC) count, C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), and PLT count were significantly higher; however, hemoglobin level and MPV were lower during exacerbation. There was a correlation between PLT and CRP, WBC, and ESR, and a negative correlation between PLT and forced vital capacity and forced expiratory volume in 1 s. However, we found an inverse correlation between MPV and WBC, and ESR, a positive correlation between MPV and forced expiratory volume in 1 s.

Conclusion

We have found that platelet indices PLT and MPV were significant in exacerbation of bronchiectasis patients compared with stable and control patients. Cell blood count, compared with CRP and other inflammatory markers, is a more practical, useful, cost-effective laboratory examination. Not just looking at the WBC, but just taking a glance at the platelet indices would be a useful and simple way to evaluate bronchiectasis patients.

References

  1. Balci AE, Balci TA, Ozyurtan MO. Current surgical therapy for bronchiectasis:surgical results and predictive factors in 86 patients. Ann Thorac Surg. 2014;97:211–217

    Article  Google Scholar 

  2. Hodge G, Upham JW, Chang AB, Baines KJ, Yerkovich ST, Pizzutto SJ, et al. Increased peripheral blood pro-inflammatory/cytotoxic lymphocytes in children with bronchiectasis. PloS One 2015; 10:e0133695.

    Article  CAS  Google Scholar 

  3. Wilson CB, Jones PW, O’Leary CJ, Hansell DM, Dowling RB, Cole P, et al. Systemic markers of inflammation in stable bronchiectasis. Eur Respir J. 1998;12:820–824.

    Article  CAS  Google Scholar 

  4. Ergan Arsava B, Coplu L. Does airway colonization cause systemic inflammation in bronchiectasis. Tuberk Toraks 2011;59:340–347.

    Article  Google Scholar 

  5. Hill SL, Burnett D, Hewetson KA, Stockley RA. The response of patients with purulent bronchiectasis to antibiotics for four months. Q J Med 1988;66:163–173.

    CAS  PubMed  Google Scholar 

  6. Valletta EA, Rigo A, Bonazzi L, Zanolla L, Mastella G. Modification of some markers of inflammation during treatment for acute respiratory exacerbation in cystic fibrosis. Acta Paediatr 1992;81:227–230.

    Article  CAS  Google Scholar 

  7. Smith RP, Lipworth BJ, Cree IA, Spiers EM, Winter JH. C-reactive protein. A clinical marker in community acquired pneumonia. Chest 1995;108:1288–1291.

    Article  CAS  Google Scholar 

  8. Martinez-Garcia MA, Perpina-Tordera M, Roman-Sanchez P, Soler-Cataluna JJ, Carratal A, Yago M, et al. Association between bronchiectasis, systemic inflammation and tumour necrosis factor α. Arch Bronconeumol 2008;44:8–14.

    PubMed  Google Scholar 

  9. Dente FL, Bilotta M, Bartoli ML, Bacci E, Cianchetti S, Latorre M, et al. Neutrophilic bronchial inflammation correlates with clinical and functional findings in patients with noncystic fibrosis bronchiectasis. Mediators Inflamm 2015; 2015:642503.

    Article  Google Scholar 

  10. Barnes PJ, Celli BR. Systemic manifestations and comorbidities in COPD. Eur Respir J 2009;33:1165–1185.

    Article  CAS  Google Scholar 

  11. Hodge G, Mukaro V, Holmes M, Reynolds P, Hodge S. Enhanced cytotoxic function of natural killer and natural killer T-like cells with associated decreased CD94 (Kp43)in the chronic obstructive pulmonary disease airway. Respirology 2013;18:369–376.

    Article  Google Scholar 

  12. Jenne CN, Kubes P. Platelets in inflammation and infection. Platelets 2015;26:286–292.

    Article  CAS  Google Scholar 

  13. Tozkoparan E, Deniz O, Ucar E, Bilgic H, Ekiz K. Changes in platelet count and indices in pulmonary tuberculosis. Clin Chem Lab Med 2007;45:1009–1013.

    Article  CAS  Google Scholar 

  14. Unsal E, Aksaray S, Koksal D, Sipit T. Potential role of interleukin 6 in reactive thrombocytosis and acute phase response in pulmonary tuberculosis. Postgrad Med J 2005;81:604–607.

    Article  CAS  Google Scholar 

  15. Yüksel O, Helvaci K, Başar O, Köklü S, Caner S, Helvaci N, Abayli E, Altiparmak E. Overlooked indicator of disease activity in ulcerative colitis:mean platelet volume. Platelets 2009;20:277–281.

    Article  Google Scholar 

  16. Yazici S, Yazici M, Erer B, Calik Y, Ozhan H, Ataoglu S. The platelet indices in patients with rheumatoid arthritis:mean platelet volume reflects disease activity. Platelets 2010;21:122–125.

    Article  CAS  Google Scholar 

  17. Dodd JD, Lavelle LP, Fabre A, Brady D. Imaging in cystic fibrosis and non-cystic fibrosis bronchiectasis. Semin Respir Crit Care Med 2015;36:194–206.

    Article  Google Scholar 

  18. Pasteur MC, Bilton D, Hill AT; British Thoracic Society Bronchiectasis non-CF Guideline Group. British Thoracic Society guideline for non-CF bronchiectasis. Thorax 2010; 65(Suppl 1):i1–i58.

    Article  Google Scholar 

  19. Hill AT, Haworth CS, Aliberti S, Barker A, Blasi F, Boersma W, et al. Pulmonary exacerbation in adults with bronchiectasis:a concensus definition for clinical research. Eur Respir J 2017; 49:1700051.

    Article  Google Scholar 

  20. Silva Filho LV, Pinto LA, Stein RT. Use of macrolides in lung diseases:recent literature controversies. J Pediatr (Rio J) 2015; 91(Suppl 1):S52–S60.

    Article  Google Scholar 

  21. Meter sky ML. New treatment options for bronchiectasis. Ther Adv Respir Dis 2010;4:93–99.

    Article  Google Scholar 

  22. Uysal P, Tuncel T, Olmez D, Babayıgıt A, Karaman O, Uzuner N. The role of mean platelet volume predicting acute exacerbations of cystic fibrosis in children. Ann Thorac Med 2011;6:227–230.

    Article  Google Scholar 

  23. Makay B, Türkyilmaz Z, Unsal E. Mean platelet volume in children with familial Mediterranean fever. Clin Rheumatol 2009;28:975–978.

    Article  Google Scholar 

  24. Mirsaeidi M, Peyrani P, Aliberti S, Filardo G, Bordon J, Blasi F, et al. Thrombocytopenia and thrombocytosis at time of hospitalization predict mortality in patients with community-acquired pneumonia. Chest 2010;137:416–420.

    Article  Google Scholar 

  25. Aydemir H, Piskin N, Akduman D, Kokturk F, Aktas E. Platelet and mean platelet volume kinetics in adult patients with sepsis. Platelets 2015;26:331–335.

    Article  CAS  Google Scholar 

  26. Gunluoglu G, Ertan Yazar E, Simsek Veske N, Seyhan EC, Altin S. Mean platelet volume as an inflammation marker in active pulmonary tuberculosis. Multidiscip Respir Med 2014; 9:11.

    Article  Google Scholar 

  27. Morris CD, Bird AR, Nell H. The haematological and biochemical changes in severe pulmonary tuberculosis. Q J Med 1989;73:1151–1159.

    CAS  Google Scholar 

  28. Bozóky G, Ruby E, Góhér I, Tóth J, Mohos A. Hematologic abnormalities in pulmonary tuberculosis. Orv Hetil 1997;138:1053–1056.

    PubMed  Google Scholar 

  29. Koc I, Dogan Y, Dokme A, Kaya A, Karatas ZA, Mandollu E, et al. Assessment of mean platelet volumes and platelet distribution widths in patients with bronchiectasis. Ankara Med J 2015;15:16–20.

    Article  Google Scholar 

  30. Uysal P, Tuncel T, Erge DO, Hocaoglu AB, Karaman O, Uzuner N. Does mean platelet volume in children with bronchiectasis predict exacerbations? Int J Hematol Oncol 2014;24:54–59.

    Article  Google Scholar 

  31. Karadag-Oncel E, Ozsurekci Y, Kara A, Karahan S, Cengiz AB, Ceyhan M. The value of mean platelet volume in the determination of community acquired pneumonia in children. Ital J Pediatr 2013; 39:16.

    Article  Google Scholar 

  32. Ali AR. Role of mean platelet volume in pat,ents with chronic obstructive pulmonary disease. Egypt J Bronchol 2016;10:251–260.

    Article  Google Scholar 

  33. Helmy TA, Baess AI, Algarahi AA. Mean platelet volume as an inflammatory marker in acute exacerbation of chronic obstructive pulmonary disease. Egypt J Bronchol 2016; 10:46.

    Article  Google Scholar 

  34. Guan WJ, Gao YH, Xu G, Lin ZY, Tang Y, Li HM, et al. Inflammatory responses, spirometry and quality of life in subjects with bronchiectasis exacerbations. Respir Care 2015;60:1180–1189.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chest Diseases, Yedikule Research and Training Hospital for Chest Diseases and Chest Surgery, Belgradkapiyolu Number 1 Zeytinburnu, Istanbul, Turkey

    Burcu A. Yigitbas MD, Yurt Sibel, Uslu Berat, Celal Satici & Kosar F. Ayse

  2. Department of Chest Diseases, Acibadem University School of Medicine, Acibadem Atakent Hospital, Istanbul, Turkey

    Uysal Pelin

Authors
  1. Burcu A. Yigitbas MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yurt Sibel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Uslu Berat
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Celal Satici
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Uysal Pelin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kosar F. Ayse
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Burcu A. Yigitbas MD.

Additional information

This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yigitbas, B.A., Sibel, Y., Berat, U. et al. Relationship between platelet count, platelet indices, and inflammatory markers in stable and acute exacerbation of bronchiectasis patients. Egypt J Bronchol 12, 173–179 (2018). https://doi.org/10.4103/ejb.ejb_62_17

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.4103/ejb.ejb_62_17

Keywords