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Respiratory failure in a patient with treated thymoma: A blast from the past


Thymomas are among the most common anterior mediastinal tumors that can uncommonly present with respiratory failure. This case discusses the development of type II respiratory failure in a patient with a history of treated and cured thymoma. The problem posed and the workup leading to the diagnosis is discussed in detail. Further, the possible and reported causes of respiratory failure in such a case has also been highlighted.


  1. Pascuzzi RM, Phillips LH II, Johns TR, Lennon VA. The prevalence of electrophysiological and immunological abnormalities in asymptomatic relatives of patients with myasthenia gravis. Ann N Y Acad Sci 1987; 505:407–415.

    CAS  Article  Google Scholar 

  2. Younger DS, Worrall BB, Penn AS. Myasthenia gravis: historical perspective and overview. Neurology 1997; 48:S1–S7.

    Article  Google Scholar 

  3. Safieddine N, Liu G, Cuningham K, Ming T, Hwang D, Brade A, et al. Prognostic factors for cure, recurrence and long-term survival after surgical resection of thymoma. J Thorac Oncol 2014; 9: 1018–1022.

    Article  Google Scholar 

  4. Kim WH, Kim JH, Kim EK, Yun SP, Kim KK, Kim WC, et al. Myasthenia gravis presenting as isolated respiratory failure: a case report. Korean J Intern Med 2010; 25:101–104.

    Article  Google Scholar 

  5. Soleimani A, Moayyeri A, Akhondzadeh S, Sadatsafavi M, Tavakoli Shalmani H, Soltanzadeh A. Frequency of myasthenic crisis in relation to thymectomy in generalized myasthenia gravis: a 17-year experience. BMC Neurol 2004; 4:12.

    Article  Google Scholar 

  6. Zueras R, Casas JI, Tarradell R, Fernández JA, Villar JM. Acute respiratory insufficiency following thymectomy: an unusual cause [in Spanish]. Rev Esp Anestesiol Reanim 1989; 36:51–53.

    CAS  PubMed  Google Scholar 

  7. Ostrowska M, de Carvalho M. Prognosis of phrenic nerve injury following thoracic interventions: four new cases and a review. Clin Neurol Neurosurg 2012; 114:199–204.

    Article  Google Scholar 

  8. Rini BI, Gajewski TF. Polymyositis with respiratory muscle weakness requiring mechanical ventilation in a patient with metastatic thymoma treated with octreotide. Ann Oncol 1999; 10:973–979.

    CAS  Article  Google Scholar 

  9. Xie G, Li L, Liu H, Xu K, Zhu Y. Diffuse panbronchiolitis complicated with thymoma: a report of 2 cases with literature review. Chin Med J (Engl) 2003; 116:1723–1727.

    Google Scholar 

  10. Colaco C, Colaco B, Mittadodla PS, Badireddi S. Respiratory failure in a patient with metastatic thymoma and myasthenia gravis: a therapeutic challenge. Am J Respir Crit Care Med 2014; 189:A2928.

    Google Scholar 

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Correspondence to Animesh Ray.

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Ray, A., Nangia, V., Chatterji, R. et al. Respiratory failure in a patient with treated thymoma: A blast from the past. Egypt J Bronchol 11, 168–170 (2017).

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  • metastasis
  • myasthenia gravis
  • respiratory failure
  • thymoma