Skip to main content
  • Original article
  • Open access
  • Published:

Assessment of prescription practices according to international chronic obstructive pulmonary disease guidelines on Egyptian doctors

Abstract

Background and objectives

Chronic obstructive pulmonary disease (COPD) is defined as ‘a preventable and treatable disease with some significant extrapulmonary effects that may contribute to the severity in individual patients’. Its pulmonary component is characterized by airflow limitation that is not fully reversible. There is a wide variation in physicians’ management of the condition, and this may be ascribed to nonadherence to the guidelines. Adherence to COPD guidelines in clinical practice in most countries is not satisfactory.

Aim

The aim of this work is to assess the prescription pattern and clinical practice attitudes toward Egyptian COPD patients managed by chest physicians and internal medicine physicians in Abbassia Chest Hospital and Ain Shams University Hospitals during the period from February 2013 to January 2014.

Patients and methods

In this study, one questionnaire was specifically directed to physicians. Sixty doctors were at Abbassia Chest Hospital, 63 at Ain Shams University Hospitals, and six doctors at Ministry Hospitals. Doctors were chest residents (29.5%), chest physicians with masters degree (33.3%), chest physicians with MD (13.2%), or internal medicine doctors (34%).

Results

Only 53 physicians performed spirometry. Most of the physicians prescribed antibiotics and systemic steroids to their patients in exacerbations. Macrolides, cephalosporins, and quinolones were the most commonly prescribed antibiotics by physicians in COPD exacerbations. Only 46 physicians used noninvasive ventilation in hypercapnic respiratory failure. Only 33 physicians were following GOLD 2013 guidelines.

Conclusion

Doctors’ awareness of guidelines is suboptimal; major deviations from the GOLD guidelines were in the form of underuse of spirometry, smoke cessation programs, and of noninvasive ventilation in exacerbations and lack of use of pulmonary rehabilitation treatment.

References

  1. Juvelekian G, Solter JK. Chronic obstructive pulmonary disease. Cleveland clinic center of continuing education. 2012. Available at: http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/pulmonary/chronic-obstructive-pulmonary-disease/. [Last accessed 2016 Feb 20].

  2. Marquis K, Maltais F, Duguay V, Bezeau AM, LeBlanc P, Jobin J, et al.The metabolic syndrome in patients with COPD. J Cardiopulm Rehabil 2005; 25:226–232.

  3. Mannino DM, Thorn D, Swensen A, Holguin F. Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD. Eur Resp J 2008; 32:962–969.

    Article  CAS  Google Scholar 

  4. Foster JA, Yawn BP, Abdolrasulnia M, Todd J, Rennard SI, Linda C. Enhancing COPD management in primary care settings. Med Gen Med 2007; 9:24.

    Google Scholar 

  5. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. Wisconsin, USA: National Institute of Health, National Heart, Lung and blood Institute and World Health Organization 2011. Available at: http://www.goldcopd.com

  6. World Health Organization. World health statistics. Geneva: WHO Press; 2008.

  7. Roche N, Lepage T, Bourcereau J, Terrioux P. Guidelines versus clinical practice in the treatment of chronic obstructive pulmonary disease. Eur Respir J 2001; 18:903–908.

    Article  CAS  Google Scholar 

  8. Rennard S, Decramer M, Calverley PM, Pride NB, Soriano JB, Vermeire PA, et al. Impact of COPD in North America and Europe in 2000: subjects’ perspective of confronting COPD International Survey. Eur Respir J 2002; 20:799–805.

    Article  CAS  Google Scholar 

  9. de Miguel J, Izquierdo JL, Rodríguez JM, de Lucas P, Molina J. Drug treatment of chronic obstructive pulmonary disease on two levels of patient care: degree of compliance with recommended protocols. Arch Bronconeumol 2003; 39:195–202.

    Google Scholar 

  10. Miravitlles M, Ferrer M, Pont A, Viejo JL, Masa JF, Gabriel R, et al. Characteristics of a population of COPD patients identified from a population-based study. Focus on previous diagnosis and never smokers. Respir Med 2005; 99:985–995.

    Article  Google Scholar 

  11. Sen E, Guclu SZ, Kibar I, Ocal U, Yilmaz V, Celik O, et al. Adherence to GOLD guideline treatment recommendations among pulmonologists in Turkey. Int J Chron Obstruct Pulmon Dis 2015; 10:2657–2663.

    Article  Google Scholar 

  12. López-Campos JL, Abad Arranz M, Calero-Acuña C, Romero-Valero F, Ayerbe-García R, Hidalgo-Molina A, et al. Guideline adherence in outpatient clinics for chronic obstructive pulmonary disease:results from a clinical audit. PLoS One 2016; 11:e0151896.

    Article  Google Scholar 

  13. Visentin E, Nieri D, Vagaggini B, Peruzzi E, Paggiaro P. An observation of prescription behaviors and adherence to guidelines in patients with COPD: real world data from October 2012 to September 2014. Curr Med Res Opin 2016; 32:1493–1502.

  14. Abbas AM, El-Faramawy MA, El-Sharkawy SH. Evaluation of prescription practices of antibiotics in respiratory tract infections at Ain Shams University Hospital [thesis submitted for partial fulfillment of Master Degree in Chest Diseases and Tuberculosis]. Cairo: Ain Shams University; 2007.

  15. Desalu OO, Onyedum CC, Adeoti AO, Gundiri LB, Fadare JO, Adekeye KA, et al. Guideline-based COPD management in a resource-limited setting – physicians’ understanding, adherence and barriers: a cross-sectional survey of internal and family medicine hospital-based physicians in Nigeria. Prim Care Respir J 2013; 22:79–85.

    Article  Google Scholar 

  16. Glaab T, Vogelmeier C, Hellmann A, Buhl R. Guideline based survey of outpatient COPD management by pulmonary specialists in Germany. Int J COPD 2012; 7:101–108.

    Article  Google Scholar 

  17. Barr RG, Celli BR, Martinez FJ, Ries AL, Rennard SI, Reilly JJ Jr, et al. Physician and patient perceptions in COPD: the COPD resource network needs assessment survey. Am J Med 2005; 118:1415.

    Article  Google Scholar 

  18. Decramer M, Bartsch P, Pauwels R, Yernault JC. Management of COPD according to guidelines. A national survey among Belgian physicians. Monaldi Arch Chest Dis 2003; 59:62–80.

    CAS  PubMed  Google Scholar 

  19. Maio S, Baldacci S, Martini F, Cerrai S, Sarno G, Borbotti M, et al. COPD management according to old and new GOLD guidelines: an observational study with Italian general practitioners. Curr Med Res Opin 2014; 30:1033–1042.

    Article  CAS  Google Scholar 

  20. Salinas GD, Williamson JC, Kalhan R, Thomashow B, Scheckermann JL, Walsh J, et al. Barriers to adherence to chronic obstructive pulmonary disease guidelines by primary care physicians. Int J Chron Obstruct Pulmon Dis 2011; 6:171–179.

    Article  Google Scholar 

  21. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. Wisconsin, USA: National Institute of Health, National Heart, Lung and blood Institute and World Health Organization 2013. Available at: http://www.goldcopd.com

  22. Vestbo J, Hurd SS. Agusti AG, Jones PW, Vogelmeier C, Anzueto A, et al. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease, GOLD executive summary. Am J Respir Crit Care Med 2013; 187:347–365.

    Article  CAS  Google Scholar 

  23. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2007; 176:532–555.

    Article  Google Scholar 

  24. Agusti A, Sobradillo P, Celli B. Addressing the complexity of chronic obstructive pulmonary disease: from phenotypes and biomarkers to scale-free networks, systems biology, and P4 medicine. Am J Respir Crit Care Med 2011; 183:1129–1137.

    Article  Google Scholar 

  25. Conti G, Antonelli M, Navalesi P, Rocco M, Bufi M, Spadetta G, et al. Noninvasive vs. conventional mechanical ventilation in patients with COPD after failure of medical treatment in the ward: a randomized trial. Intensive Care Med 2002; 28:1701–1707.

    Article  CAS  Google Scholar 

  26. Peter JV, Moran JL, Phillips-Hughes J, Warn D. Noninvasive ventilation in acute respiratory failure a meta-analysis update. Crit Care Med 2002; 30:555–562.

    Article  Google Scholar 

  27. Adaira L, Mark F, Alex K. Noninvasive ventilation for acute respiratory failure: a prospective randomized placebo- controlled trial. Eur Respir J 2002; 20:545–555.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Nasr H. Kahlil MD.

Additional information

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work noncommercially, as long as the author is credited and the new creations are licensed under the identical terms.

Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kahlil, N.H., Abdel-Hamid, H.M. & Mohammed, Y.M. Assessment of prescription practices according to international chronic obstructive pulmonary disease guidelines on Egyptian doctors. Egypt J Bronchol 11, 193–202 (2017). https://doi.org/10.4103/ejb.ejb_75_16

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.4103/ejb.ejb_75_16

Keywords