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Bronchial asthma: clinical phenotypes and endotypes and their relation with glucocorticoids circadian rhythm and parasympathetic activity

Egyptian Journal of Bronchology volume 12, pages 154–159 (2018)Cite this article

Abstract

Introduction

Asthma is a heterogeneous disease and presents in different clinical patterns ‘phenotypes’ as a result of diverse pathobiological background ‘endotypes’.

Objectives

Theaim of this studywas to study serum interleukin-13 (IL-13) levels and the frequency of (IL-13) +1923C/T gene polymorphism in Egyptian children with asthma and to study glucocorticoids circadian rhythm in nocturnal asthma.

Patients and methods

The frequency of (IL-13) +1923C/T gene polymorphism genotypes was determined in 114 asthmatic Egyptian children and compared with a matched group of 152 healthy controls using PCR. Serum IL-13 and cortisol a.m. and p.m. concentrations in serum were assessed using enzyme linked immunosorbent assay.

Results

Serum IL-13 was found to be significantly higher in asthmatic patients when compared with the control group (P<0.0001). In the asthmatic group, forced expiratory volume in 1 s showed a significant negative correlation with serum IL-13 (ρ=−0.2, P=0.03), whereas peripheral blood eosinophilic % showed a significant positive correlation with serum IL-13 (ρ =0.18, P=0.05). No statistically significant differences were found between asthmatic patients and controls in IL-13 C1923T genotype frequency. A significantly lower serum cortisol pm was found in asthmatic patients with nocturnal symptoms when compared with those without nocturnal symptoms (P<0.0001).

Conclusion

Serum IL-13 is significantly higher in asthmatic patients when compared with controls. (IL-13) +1923C/T gene polymorphism is not a risk factor for development of asthma in Egyptian children. Nocturnal symptoms in some asthmatic patients can be partly attributed to lower serum cortisol level at night.

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Author information

Authors and Affiliations

  1. Respiratory and Clinical Immunology Department, Mansoura University, Faculty of Medicine, Egypt

    Magdy M. Zedan (Professor of Allergy)

  2. Mansoura University Children’s Hospital, Al-Gomhoria Street, 35516, Mansoura, Egypt

    Magdy Abd El Moneim El-Ziny (Professor of Pediatrics), Abd Elazeez Atallah Shabaan (Professor of Clinical Pathology), Youssef M. Mosaad (Lecturer of Pediatrics) & Wafaa Nabil Laimon MD degree in Pediatrics (Lecturer of Pediatrics)

Authors
  1. Magdy M. Zedan
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  2. Magdy Abd El Moneim El-Ziny
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  3. Abd Elazeez Atallah Shabaan
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  4. Youssef M. Mosaad
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  5. Wafaa Nabil Laimon MD degree in Pediatrics
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Correspondence to Wafaa Nabil Laimon MD degree in Pediatrics.

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Zedan, M.M., Moneim El-Ziny, M.A.E., Shabaan, A.E.A. et al. Bronchial asthma: clinical phenotypes and endotypes and their relation with glucocorticoids circadian rhythm and parasympathetic activity. Egypt J Bronchol 12, 154–159 (2018). https://doi.org/10.4103/ejb.ejb_8_17

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  • DOI: https://doi.org/10.4103/ejb.ejb_8_17

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