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Drug-related factors affecting medication adherence among Egyptian asthma patients

A Correction to this article was published on 10 November 2020

This article has been updated

Abstract

Background

The aim of this study is to evaluate adherence to inhaler therapy in asthmatic patients and examine drug-related factors affecting medication adherence among Egyptian asthma patients. The study was carried out among 110 clinically diagnosed asthma patients attending at a university hospital, Sohag, Egypt. Inhaler criteria and adherence were evaluated by a standardized tool “Morisky Medication Adherence Scale (MMAS), 2008.”

Results

The study revealed that out of 110 patients, 42.2% had a high level, 22.9% had medium level, and 34.9% had a low level of medication adherence. There was no relationship between demographic data and medication adherence in asthmatic patients. However, good adherence was frequently encountered among asthmatic patients who used inhaler twice daily, who used drugs its onset of action 5-20 min, who used aerolizer and turbo haler devices, and who used budesonide and budesonide/formoterol.

Conclusions

Poor adherence to inhaler therapy is high in patients with bronchial asthma attending Sohag University Hospital in Upper Egypt. There was a strong relationship between inhaled drug criteria and degree of adherence in asthmatic patients.

Background

Poor adherence to inhaler therapy in patients with bronchial asthma increases mortality, morbidity, and hospital visits [1, 2].

Increasing medication adherence is important to increase the benefits of inhaled treatment. So, assessment of the level of adherence to the inhaler therapy in asthmatic patients becomes essential in daily practice [2].

By opposition, poor adherence leads to poor clinical outcomes, an increase in morbidity and mortality, and unnecessary healthcare expenses [3]. Few studies have assessed adherence to asthma medications in Egypt. We aimed to evaluate adherence to inhaled therapy in asthmatic patients and to examine drug-related factors affecting medication adherence.

Methods

Study subjects and design

A descriptive cross-sectional study design was used, and 110 asthma patients were selected from the inpatient department and outpatient clinic of chest diseases, Sohag University Hospitals. Before the data collection, this study was approved by the ethical committee of Sohag University Hospitals and an informed consent was taken from the patients.

After taking informed consent from the patients, the informations regarding age, sex, literacy, residence, occupation, smoking habits, socioeconomic status, comorbidities, date of diagnosis of asthma, and pulmonary function tests were recorded.

Inhaler use

Further questions related to the currently prescribed aerosol therapy for asthma-like number of medications prescribed per day, type of device, type of drug, onset of action of inhaler, and frequency of administration of inhaler.

The current prescribed medications for asthma were identified for all included patients: inhaled steroids (ICS), long-acting β2-agonists (LABA), combined LABA/ICS, short-acting β2-agonists, short-acting anticholinergics, and long-acting anticholinergics. Most patients were on combination therapy.

Level of adherence

Level of adherence was examined by the eight-item Morisky Medication Adherence Scale (MMAS-8) [4]. According to MMAS-8, the level of adherence was high adherence (score, 8), moderate adherence (score, 6 to < 8), and low adherence (score, < 6). Patients with low or moderate level of adherence were considered non-adherent.

Statistical analysis

SPSS version 20 (SPSS Inc., Chicago, IL, USA) was used, and data is presented as mean ± standard deviations. To compare between groups, χ2 test and the ANOVA test were used. P value of ≤ 0.05 was considered significant.

Results

The clinical data of studied patients are depicted in Table 1. A total of 110 included in the study. The age of patients was 39.22 ± 13.51 years. Most of the patients were females (69/41; 62.72%). Fifty percent of patients are illiterate. The most commonly used inhaled therapy in asthma patients is presented in Table 1.

Table 1 Patients with asthma according to medications

As regard frequency of administration of inhaler, it was found that asthma patients were frequently using the inhaler twice daily; also, asthmatic patients used the on need more frequently. As regard the onset of action of inhaler, it was found that the inhaler of 5 min of onset of action was frequently used by asthma patients than other types of inhalers. As regard type of device, it was found that aerolizer, metered-dose inhaler (MDI), turbo haler, and hand haler were frequently used by asthma in order than other types of devices. As regard type of drug, it was found that budesonide, formoterol, salbutamol, and budesonide/formoterol were frequently used by asthma in order than other types of drugs.

The different categories of adherence are shown in Fig. 1. A total of 42.2% of patients had good adherence, 22.9% intermediate adherence, and 34.9% poor adherence.

Fig. 1
figure 1

Level of adherence among patients with bronchial asthma

Table 2 shows the relation between demographic data and adherence in asthmatic patients already on inhaler therapy. No significant relationship between demographic data and medication adherence was found in asthmatic patients (P > 0.05).

Table 2 Relation between demographic data and adherence pattern in asthmatic patients already on therapy (n = 110)

The relation between drug characteristics and adherence patterns in asthma patients already on therapy is shown in Table 3 (Fig. 2 a-d). Adherence pattern was significantly associated with frequency of administration, onset of action, type of device, type of drug with P = (0.001, 0.002, 0.001, 0.001) respectively. It was found that good adherence frequently encountered among patients who used inhaler twice daily, who used drugs its onset of action < 5-20 min, who used aerolizer and turbo haler, and who used budesonide/formoterol and budesonide only.

Table 3 Relation between drug characteristics and adherence pattern in asthmatic patients already on therapy (n = 110)
Fig. 2
figure 2

The relation between drug characteristics and adherence pattern in asthma patients. a Frequency of administration. b Onset of action of inhaler. c Type of device. d Type of drug

Discussion

Poor adherence was associated with poor clinical outcomes among asthma patients. So that our study aimed at determining factors affecting inhaled therapy adherence in asthma patients using the MMAS-8 [5, 6].

The study was conducted in 110 asthma patients among which 69 were female and the other 41 were male. The mean age was of 39.22 ± 13.51 years. A total of 52.72% came from urban area, 86.36% had middle socioeconomic class, and 50% was illiterate. The duration of asthma was 11.21 ± 8.91 years. More than half (75.45%) of the patients had one comorbidity.

Among the studied population, poor adherence was observed in 34.9%, 22.9% intermediate adherence, and 42.2% of patients had good adherence. This result matches with the results of those who found that adherence among asthmatic patients was 49% [7, 8]. These results show that many patients with bronchial asthma are not adherent to their inhaled therapy. A previous study shows that inhaled therapy adherence is worse than other medications in asthmatic patients [9,10,11,12]. In other studies, medication adherence rates have consistently been shown to be 30–40% and may increase as high as 70% among asthma patients [9, 13,14,15,16]. This discrepancy in findings may be due to the difference in knowledge regarding asthma among participants, the use of different questionnaires, and the inclusion of different groups of the sample population in the study.

In this study, none of the sociodemographic informations (such as age, gender, place of residence, educational status, comorbidity, severity of symptoms, and smoking habit) were associated with patients’ level of medication adherence. Consistent to these findings, Senior et al. showed that patients’ level of medication adherence was not associated with sociodemographic and clinical variables (age, gender, marital status, and place of residence, education, type of occupation and current smoking status, and severity of asthma [17]. However, these findings are contradictory with other studies [18]. The difference in findings might be due to the inclusion of patients of different duration of disease, different study designs, and use of different validated questionnaires in the studies.

As regard frequency of administration of inhaler in our study, we found that 75.5% preferred twice-daily therapy, 2.7% preferred once daily, and 21.8% used inhaler on need. There was a statistically significant association between good adherence and the use of inhaler twice daily in asthmatic patients in comparison with the use of on-need inhaler. However, this result is not comparable with Venables et al. [19]. Other studies found that adherence in asthmatic patients were unrelated to frequent uses of inhaler therapy [20,21,22]. Others observed that reliever inhalers were frequently used in asthmatic patients [23, 24].

As regard onset of action of inhaler, we found that the inhaler of 5-20 min of onset of action was frequently used by patients than other types of inhalers and this was statistically significant, this result due to asthma patients almost always complaining and need rescue bronchodilators medications which are rapidly acting, also, the drug-delivering its action rapidly lead the patient to continue taking the drug daily [25].

In our study, there was a statistically significant association between adherence and the use of turbo haler and aerolizer in asthmatic patients in comparison with the use of MDI. Our study result agrees with a previous study, which found that using dry-powder inhalers (DPIs) versus metered-dose inhalers (MDIs) was associated to adherence [26].

Moreover, a significant relationship was found between good adherence and budesonide/formoterol and budesonide in asthmatic patients in comparison with the use of salbutamol. This observation agrees with that of Axelsson et al. [27] and Stempel et al. [28]

Conclusion

Adherence to inhaler therapy is low in Egyptian asthmatics. Type of device, type of drug, onset of action of inhaler, and frequency of administration of inhaler significantly affect medication adherence in asthma patients.

Availability of data and materials

The datasets used during the current study are available from the corresponding author on reasonable request.

Change history

  • 10 November 2020

    An amendment to this paper has been published and can be accessed via the original article.

Abbreviations

ICS:

Inhaled steroids

LABA:

Long-acting β2-agonists

MMAS-8:

Eight-item Morisky Medication Adherence Scale

SPSS:

Statistical Package for the Social Sciences

MDI:

Metered-dose inhaler

DPIs:

Dry-powder inhalers

References

  1. Melani AS, BonaviaM CV, Cinti C, Lodi M, Martucci P et al (2011) Gruppo Educazionale Associazione Italiana Pneumologi Ospedalieri: inhaler mishandling remains common in real life and is associated with reduced disease control. Respir Med 105:930–938

    Article  Google Scholar 

  2. Rau JL (2005) Determinants of patient adherence to aerosol regimen. Respir Care 50:1346–1356

    Google Scholar 

  3. Brown, Marie T.; Bussell, Jennifer K (2011). Medication adherence: WHO cares. In: Mayo Clinic Proceedings. Elsevier, . P. 304-314.

  4. Morisky DE, Ang A, Krousel-Wood M, Ward HJ (2008) Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens 10:348–354

    Article  Google Scholar 

  5. Chiu KC, Boonsawat W, Cho SH (2014) Patients’ beliefs and behaviors related to treatment adherence in patients with asthma requiring maintenance treatment in Asia. J Asthma 51(6):652–659

    CAS  Article  Google Scholar 

  6. Baker CL, Gupta S, Goren A, Willke RJ (2013) Adherence and satisfaction with oral versus other treatments among patients with chronic obstructive pulmonary disease (COPD) in the U.S. 2012 national health and wellness survey. Value Health 16(3):A236–A237

    Article  Google Scholar 

  7. Nizar Rifaat, Elham Abdel-Hady and Ali A. Hasan (2013) Egyptian Journal of Chest Diseases and Tuberculosis 62, 371–376.

  8. Ayele AA, Tegegn HG (2017) Non adherence to inhalational medications and associated factors among patients with asthma in a referral hospital in Ethiopia, using validated tool TAI. Asthma Res Pract 3:7

    Article  Google Scholar 

  9. Jones C, Santanello NC, Boccuzzi SJ, Wogen J, Strub P, Nelsen LM (2003) Adherence to prescribed treatment for asthma: evidence from pharmacy benefits data. J Asthma 40:93e101

    Article  Google Scholar 

  10. McNally KA, Rohan J, Schluchter M, Riekert KA, Vavrek P, Schmidt A et al (2009) Adherence to combined montelukast and fluticasone treatment in economically disadvantaged African American youth with asthma. J Asthma 46:921e7

    Article  Google Scholar 

  11. Fitzpatrick AM, Kir T, Naeher LP, Fuhrman SC, Hahn K, Teague WG (2009) Tablet and inhaled controller medication refill frequencies in children with asthma. J Pediatr Nurs 24:81e9

    Article  Google Scholar 

  12. Rand C, Bilderback A, Schiller K, Edelman JM, Hustad CM, Zeiger RS et al (2007) Adherence with montelukast or fluticasone in a long-term clinical trial: results from the mild asthma montelukast versus inhaled corticosteroid trial. J Allergy Clin Immunol 119:916e23

    Article  Google Scholar 

  13. Bozek A, Jarzab J (2010) Adherence to asthma therapy in elderly patients. J Asthma 47:162–165

    Article  Google Scholar 

  14. Latry P, Pinet M, Labat A, Magand JP, Peter C, Robinson P et al (2008) Adherence to anti-inflammatory treatment for asthma in clinical practice in France. Clin Ther 30:1058–1068

    Article  Google Scholar 

  15. Clerisme-Beaty EM, Bartlett SJ, Teague WG, Lima J, Irvin CG, Cohen R (2011) The Madison avenue effect: how drug presentation style influences adherence and outcome in patients with asthma. J Allergy Clin Immunol 127:406–411

    Article  Google Scholar 

  16. Rand CS, Wise RA (1994) Measuring adherence to asthma medication regimens. Am J Respir Crit Care Med 149:69–78

    Article  Google Scholar 

  17. Senior V, Marteau TM, Weinman J (2004) Self-reported adherence to cholesterol-lowering medication in patients with familial hyper cholesterolaemia: the role of illness perceptions. 18(6):475–481

  18. Hertz RB, Unger AN, Lustik MB (2005) Adherence with pharmacotherapy for type 2 diabetes: a retrospective cohort study of adults with employer-sponsored health insurance. Clin.Ther. 27:1064–1073

    Article  Google Scholar 

  19. Venables T (1996) A comparison of the efficacy and patient acceptability of once daily budesonide via turbohaler and twice daily fluticasone propionate via disc-inhaler at an equal daily dose of 400 μg in adult asthmatics. Br J Clin Pharmacol 7:15–32

    Google Scholar 

  20. van Schayck CP, Bijl-Hofland ID, Folgering H, Cloosterman SG, Akkermans R, van den Elshout F et al (2002) Influence of two different inhalation devices on therapy compliance in asthmatic patients. Scand J Prim Health Care 20:126–128

    Article  Google Scholar 

  21. Laforest L, El Hasnaoui A, Pribil C, Ritleng C, Osman LM, Schwalm MS et al (2009) Asthma patients’ self-reported behaviours toward inhaled corticosteroids. Respir Med 103:1366–1375

    Article  Google Scholar 

  22. Wells KE, Peterson EL, Ahmedani BK, Williams LK (2013) Real-world effects of once vs. greater daily inhaled corticosteroid dosing on medication adherence. Ann Allergy Asthma Immunol 111:216–220

    CAS  Article  Google Scholar 

  23. Bender BG, Apter A, Bogen DK, Dickinson P, Fisher L, Wamboldt FS et al (2010) Test of an interactive voice response intervention to improve adherence to controller medications in adults with asthma. J Am Board Fam Med 23:159e65

    Article  Google Scholar 

  24. Apter AJ, Reisine ST, Affleck G, Barrows E, ZuWallack RL (1998) Adherence with twice-daily dosing of inhaled steroids. Socioeconomic and health-belief differences. Am J Respir Crit Care Med 157:1810–1817

    CAS  Article  Google Scholar 

  25. Sanduzzi A, Balbo P, Candoli P, Catapano GA, Contini P, Mattei A et al (2014) COPD: adherence to therapy. Multidiscip Respir Med 9(1):60

    Article  Google Scholar 

  26. Friedman HS, Navaratnam P, McLaughlin J (2010) Adherence and asthma control with mometasone furoate versus fluticasone propionate in adolescents and young adults with mild asthma. J Asthma 47:994–1000

    CAS  Article  Google Scholar 

  27. Axelsson M, Emilsson M, Brink E, Lundgren J, Torén K, Lötvall J (2009) Personality, adherence, asthma control and health-related quality of life in young adult asthmatics. Respir Med 103:1033–1040

    CAS  Article  Google Scholar 

  28. Stempel DA, Stoloff SW, Carranza Rosenzweig JR, Stanford RH, Ryskina KL, Legorreta AP (2005) Adherence to asthma controller medication regimens. Respir Med 99:1263–1267

    CAS  Article  Google Scholar 

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Acknowledgements

Deep gratitude to all patients accepted to participate in the study.

Authors’contributions

Abdellah Hamed, Kamal Atta, and Khaled Fwazy put the design of the work, interpreted the data, writing the manuscript, and revised it. Esraa Ameen performed the procedure, data acquisition, analysis, and a contributor in writing the manuscript. All authors have read and approved the final manuscript.

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Correspondence to Abdellah H K Ali.

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Ethics approval and consent to participate

Before the data collection, this study was approved by the ethical committee of Sohag University Hospitals and an informed consent was taken from the patients.

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The authors declare that they have no competing interests.

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The author identified that Table 2 was a duplicate of Table 1. The duplicate has been deleted and the tables renumbered. The original article has been corrected.

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Ali, A.H.K., Ameen, E., Atta, K. et al. Drug-related factors affecting medication adherence among Egyptian asthma patients. Egypt J Bronchol 14, 35 (2020). https://doi.org/10.1186/s43168-020-00035-w

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