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Elimination of nasal obstruction improves pulmonary functions and oxygenation

Abstract

Background

Nasal obstruction is a significant medical problem. This study aimed to examine the effect of nasal obstruction and nasal packing on arterial blood gases and pulmonary function indices, and the impact of the elimination of nasal obstruction on preoperative values.

Results

The mean age of the study population was 26.6 ± 10.1 years, males represented 50.8%. Spirometric indices showed statistically significant improvement (preoperative forced expiratory volume in 1st second 66.9 ± 13.9 vs 79.6 ± 14.9 postoperative and preoperative forced vital capacity 65.5 ± 12.7 vs 80.4 ± 13.8 postoperative). Oxygen saturation was significantly lower during nasal packing (95.6 ± 1.6 preoperative vs 94.7 ± 2.8 with nasal pack), and significant improvement (97.2 ± 1.4) was observed after removal of the nasal pack. Nasal obstruction scores significantly improved.

Conclusion

The results of this study indicate that either simple nasal obstruction or nasal packing may cause hypoxemia and abnormalities in lung function tests. Hypoxemia was more evident with nasal packing.

Background

Nasal airway obstruction and nasal congestion are significant presentations in otorhinolaryngology practice. They carry significant discomfort, economic impact, and negative effect on the quality of life [1, 2]. The nose is the primary route of breathing in humans and it carries significant functions including humidification, warming, and filtration of inspired air [3]. In normal conditions, the nasal airway accounts for ≥ 50% of total airway resistance, with most of this contribution arising from the anterior part of the nose [4], this resistance is increased in pathologic conditions [5]. Nasal resistance is different from side to side and because of nasal mucosal changes in nasal turbinate in a cycle pattern (nasal cycle) [6]. This cycle occurs in about 80% of the adult population and this cycle plays a role in respiratory defense [7]. Changes in respiratory mechanics and arterial blood gases may occur due to oral breathing secondary to nasal obstruction [8]. In patients with permanent unilateral nasal obstruction, the nasal cycle can contribute to a significant increase in the total resistance of the airways [7]. Previous studies reported that simple nasal obstruction was associated with hypoxemia [9] and changes in respiratory function tests [10]. Nasal packing is a common practice after nasal operations. Some studies reported that nasal packing following nasal surgeries may result in hypoxemia and/or hypercapnia [11]. Other studies reported that nasal packing with airway tubes did not result in postoperative respiratory dysfunction or hypoxemia [12]. Surgical correction of nasal obstruction is a common rhinolaryngology practice; this correction may improve physiologic changes in pulmonary function and on arterial blood gases associated with nasal obstruction. This study aimed to examine the effect of nasal obstruction and nasal packing on arterial blood gases and pulmonary function indices and the impact of the elimination of nasal obstruction on preoperative values.

Methods

Study design and population

In this time series hospital-based study, we enrolled consecutive 59 patients with nasal obstruction who are eligible for corrective surgery as recommended by their management team. The study team has no role in patient selection or operative decisions.

Data collection

Detailed history was taken. Clinical examination was performed by otorhinolaryngologist; examination of the external nose and anterior rhinoscopy, and diagnostic nasal endoscope for the examination of the nasal cavity to detect the cause of nasal obstruction (polyp, septal deviation, or tumor). Respiratory assessment by pulmonologist was also performed, and patients who have evidence of chronic respiratory disease, chronic heart disease, and neuromuscular disease were excluded from the study. Age, sex, symptoms, and smoking history were recorded. Nasal obstruction symptom evaluation (NOSE) score [13] was used to assess the degree of nasal obstruction pre and postoperative. The score is formed of five items and each item represents symptom (nasal stuffiness, nasal obstruction, trouble breathing, trouble sleeping, unable to get enough air during exercise); each patient takes a score from 0 to 4 (0 represent not a problem and 4 represent a severe problem); the maximum result is 20 which will be multiplied by 5 to get a score from 100.

  1. 1.

    Routine pre-operative investigations were recorded including laboratory investigations and radiologic studies (computed tomography scan of the nose and paranasal sinus to determine the cause of nasal obstruction and plain chest radiography).

  2. 2.

    Arterial blood gases (RAPID lab blood gas analyzer Siemens) were done at three-time points for each patient: 1st sample at baseline (before surgery), 2nd sample on the 2nd postoperative day just before removal of nasal packing, while the 3rd sample was obtained 1 week postoperative after removal of the nasal pack.

  3. 3.

    Spirometry was performed and interpreted by an experienced pulmonologist according to ERS/ATS guidelines [14] using “Spirosift SP-5000 FUKUDA Denshi, Japan” spirometer. The procedure was done at two-time points: 1st measurement at baseline (pre-operative) and the 2nd measurement was done 1 week postoperative after removal of the nasal pack. The patient was asked to breathe normally several times then taking a deep breath and exhale as deep and as fast as he/she can. We recorded forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), and FEV1/FVC. This procedure is repeated three times and the best technically acceptable reading is recorded. Spirometry could not be done at the 48 h postoperative time point as the forced expiration required during test performance may increase the risk of bleeding or displacement of nasal packing.

  4. 4.

    Septoplasty was performed using the functional endoscopic sinus surgery (FESS) technique under general anesthesia and followed by a bilateral nasal packing using Tampon nasal packs.

  5. 5.

    Removal of the nasal pack was done 48 h postoperative day and the patient was examined by the otorhinolaryngologist.

Data management

All data were recorded anonymously and fed to excel, coded, and revised. Statistical analysis was performed using SPSS software for Windows (Version 20.0; SSPS Inc., Chicago, IL). Numerical data were presented as mean ± SD whereas categorical data were presented as number and percentage. The paired sample t test was used to compare numerical with normal distribution. Mann-Whitney test was used for non-parametric comparisons. The general linear model was used for the comparison of repeated measures. Multiple linear logistic regression model was done to determine factors affecting hypoxia. The level of significance was considered as p < 0.05 for all tests.

Results

Fifty-nine patients were operated on for correction of the cause of nasal obstruction between March 2018 and February 2019. Their mean age was 26.6 ± 10.1 years, males represented 50.8% of cases, 13.6% were current smokers. Nasal obstruction, rhinorrhea, postnasal discharge, and headache were the most prevalent symptoms (Tables 1 and 2). No significant statistical difference between male and female in age, BMI, duration of nasal obstruction, and baseline nasal obstruction score (p = 0.837, 0.187, 0.801, 0.717, respectively). Preoperative PaO2 was significantly higher in women than in men (p = 0.01).

Table 1 Demographic data of the studied group
Table 2 Clinical data of the studied group

Spirometric indices were impaired at baselines and showed significant improvement postoperatively (Table 3). No statistical significant difference in pulmonary functions between males and females either at baseline or postoperatively. Hypoxemia was observed in some cases pre-operatively, and there was a significant decrease in partial pressure of oxygen (PaO2), pH, and oxygen saturation (SPO2%) with nasal packing. Oxygenation significantly improved postoperatively after removal of the pack (Table 4, Figs. 1 and 2).

Table 3 Pulmonary functions and nasal obstruction score pre and postoperative
Table 4 Pre-operative with nasal pack and postoperative blood gases values
Fig. 1
figure1

Changes observed in PaO2 over time. Hypoxemia was present at baseline and a further decrease was observed with nasal packing and significant improvement was detected after removal of nasal packs

Fig. 2
figure2

Changes observed in oxygen saturation over time. Oxygen saturation was low at baseline and a further decrease was observed with nasal packing and significant improvement was detected after removal of nasal packs

FVC forced vital capacity, FEV1 forced expiratory volume in first second of forced vital capacity maneuver, NOSE nasal obstruction symptom evaluation

PaO2 partial pressure of oxygen, PaCO2 partial pressure of carbon dioxide, SPO2 oxygen saturation

Factors significantly affecting postoperative SPO2% were preoperative nasal obstruction score, RBCs number, and sex (higher SPO2 was higher when preoperative obstruction score is low, a higher number of RBCs and being a female) (Table 5).

Table 5 Multiple linear regression model of factors affecting SPO2

NOSE nasal obstruction symptom evaluation

Discussion

The results of this study revealed that patients with nasal obstruction had impaired pulmonary function tests (decreased FVC, FEV1) which are significantly improved postoperative (Table 3). Previous studies [15, 16] reported lower FEV1, FVC in patients with the nasal obstruction which improved following surgery. However; Yiğit et al. [12] reported a small non-significant reduction in the values of FEV1, FVC in patients with nasal packing. This could be attributed to the fact that they used airway tubes for packing which prevented total nasal obstruction.

Various studies [10, 17, 18] reported lower pulmonary functions in patients with chronic rhinosinusitis resistant to medical treatment. These changes may be symptomatic or asymptomatic. Yousof et al. [10] reported significantly lower values of mean FVC, FVC%, FEV1, and FEV1% in the group of patients with chronic medically resistant rhinosinusitis compared with the control healthy group which improved following surgery.

In our study, all patients had symptoms of nasal obstruction and most of them had nasal polyposis (79.7%). The effect of nasal obstruction on spirometry can be explained by the nasal-lung systemic cross-talk in which airway inflammation whatever the site is reflected on all airways either upper or lower and the presentation depends on the severity and contributing factors [19].

In our study, patients with nasal obstruction had mild hypoxemia and decreased oxygen saturation. Oxygenation was significantly impaired further with nasal packing (PaO2 slightly decreased while oxygen saturation is significantly decreased during packing). All these changes are improved 1 week postoperative following removal of the nasal pack. On the other hand, no significant changes were observed in carbon dioxide level (Table 4, Figs. 1 and 2).

The same results were reported in previous studies [16, 20,21,22]. Cassisi et al. [21] reported that nasal packing caused a significant decrease in PaO2, but it had little effect on PaCO2, and that low PO2 returned to normal after the pack had been removed. Ogretmenoglu et al. [20] showed that nasal packing caused a significant decrease in O2 saturation, a borderline decrease in PO2, insignificant changes in PCO2. Saxena et al. [22] demonstrated a significant increase in partial arterial oxygen saturation percentages, as well as peak and forced expiratory flow speed in a group of patients with deviated nasal septum 1 month after the surgical correction. Mandour et al. [16] reported statistically significant improvement in nocturnal oxygen in patients with nasal obstruction after surgery.

On the other hand, Taasan et al. [23] study failed to report significant changes in nocturnal oxygen saturation in healthy subjects with total nasal packing. However, a very small sample number (only seven patients) was included. Yigit et al. [12] conducted a study on 40 patients: 20 with nasal packing with airway tubes and 20 with nasal packing without airway tubes. Their results showed decreased PO2 and increased PCO2 in patients with nasal packing without airway tubes postoperatively. They explained these results by the hypoxia following a nasal obstruction.

The results of the current study and previous studies refer to a negative effect of nasal obstruction either pathologic or artificial by nasal packing on arterial oxygen status. This may be explained by the following: the obstructed air passage by pathologic condition and the same effect provided by the nasal packing may result in secondary hypoventilation and an increase in bronchomotor tone and activation of naso-pulmonary reflex which leads to decreased pulmonary compliance and increased pulmonary and airway resistance [21, 22]. The increased bronchomotor tone led to increased turbulence, which altered the distribution of alveolar ventilation, leading to hypoxemia [21]. Besides, mechanical obstruction of the nose may activate trigeminal receptors in nasal mucosa resulting in naso-pulmonary reflex. The pressure of nasal packs may provide additional stimulation to these receptors [22]. Nasal packing causes complete nasal obstruction leading to oral breathing and may contribute to the development of sleep-disordered breathing which leads to a further decrease in oxygen saturation [24, 25]. Other causes of venous admixture (e.g., pneumonia or right-to-left shunting) were ruled out based on an unremarkable medical history and physical examination, and radiology.

Oral breathing in cases of nasal obstruction may be a contributing factor as oral breathing reduces the activation of nasal receptors, with the deactivation of the nasal respiratory reflex and reduction of spontaneous ventilation [26].

The exact mechanism of improvement after surgery is unknown and it may be attributed to the correction of previous factors.

Our results showed that female sex, high RBCs number, and low preoperative nasal obstruction score were associated with high postoperative SPO2. This may be attributed to physiologic mechanisms as RBCs are carriers for oxygen; in those with low NOSE score, the mechanical and pathophysiologic mechanisms causing impaired oxygenation are less activated. Besides, women had significantly higher PaO2 at baseline.

Conclusions

This study finds that nasal obstruction caused lower airway obstruction. At the same time, nasal obstruction either pathologic or artificial impairs oxygenation. Surgical treatment for cases with chronic nasal obstruction may significantly improve pulmonary effects secondary to nasal obstruction. Further studies are required to determine the exact mechanism behind these effects.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Abbreviations

FVC:

Forced vital capacity

FEV1:

Forced expiratory volume in the first second of forced vital capacity maneuver

L:

Liter

PaO2:

Partial pressure of oxygen

PaCO2:

Partial pressure of carbon dioxide

SPO2:

Oxygen saturation

NOSE:

Nasal obstruction symptom evaluation

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Acknowledgements

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors

Contributions

E.S., F.E., and T. I. contributed to research conception and design, literature review, and revised the work. E.S. drafted the manuscript. F.E. and E.S. contributed to the data collection. T.S. performed the statistical analysis of the data. All authors contributed to writing and critical analysis of the work, and revised the manuscript. All authors have read and approved the manuscript.

Corresponding author

Correspondence to Eman Sobh.

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Ethics approval and consent to participate

The study protocol was approved by the ethics committee of our institute (approval number 201908128) and written informed consent was obtained from each participant before enrolment in the study, and all participants had the right to withdraw from the study at any point without giving reason and without any disadvantages of their management.

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Sobh, E., Elhussieny, F. & Ismail, T. Elimination of nasal obstruction improves pulmonary functions and oxygenation. Egypt J Bronchol 15, 32 (2021). https://doi.org/10.1186/s43168-021-00079-6

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Keywords

  • Nasal obstruction
  • Nasal packing
  • Pulmonary function tests
  • Spirometry
  • Hypoxemia
  • Arterial blood gases, Respiratory function, Airway obstruction, Oxygen saturation