A rare and late complication of lung cancer: bronchial rupture

Abstract

Background

Tracheobronchial injuries generally occur due to iatrogenic or traumatic causes. Although bronchial rupture due to teratoma and germ cell tumors has been reported in the literature, no cases related to lung cancer have been determined. Our case is presented because of the refusal to be examined for the mass in the lung and the detection of bronchial rupture afterward when he presented with massive hemoptysis.

Case presentation

A 65-year-old male patient was admitted to the emergency department with the complaint of massive hemoptysis. Six months ago, bronchoscopy was recommended due to the 8 × 7 cm cavitary lesion obliterating the bronchus in the anterior upper lobe of the right lung on chest computed tomography, but the patient refused. The sputum sample, requested 3 times, was negative for acid-resistant bacteria, and no growth was detected in the mycobacterial culture. In the new pulmonary CT angiography, a progressive cavitary lesion invading the right main bronchus, carina, and vena cava superior was observed. Following tranexamic acid treatment and bronchial artery embolization, hemoptysis significantly decreased in the follow-up. In the flexible bronchoscopy performed for diagnostic purposes, the carina was pushed to the left and invaded, and there was damage to the right main bronchus. A biopsy was not performed due to the risk of bleeding, and lavage was performed. Lavage was negative for ARB, there was no growth in the mycobacteria culture, and cytology did not reveal malignant cells. The patient, diagnosed with right main bronchial rupture, was considered inoperable and died 1 month later due to respiratory failure.

Conclusions

Examinations should be initiated as soon as malignancy is suspected. When diagnosis and treatment are delayed, complications that would be challenging to intervene may develop.

Background

Lung cancer is the most frequently diagnosed cancer type with the most mortal clinical course [1]. Symptoms in lung cancer emerge depending on the primary tumor and its intrathoracic spread, the presence of distant metastases, and the development of paraneoplastic syndrome [2]. However, the occurrence of massive hemoptysis as a result of a bronchial rupture is extremely rare. Our case, which was observed to have bronchial rupture when he presented with massive hemoptysis 6 months after refusing an examination for his lung mass, is presented to emphasize that it should not be delayed in diagnosing and treating cancer since bronchial artery embolization was performed. However, only palliative care could be recommended due to the inoperable cancer stage.

Case presentation

A 65-year-old male patient was admitted to the outpatient clinic complaining of cough, sputum, dyspnea, and chest pain. He had a 40-pack-year history of smoking and was an active smoker. On physical examination, respiratory sounds were decreased in the upper zone of the right lung. Because of the 8 × 7 cm cavitary lesion obliterating the bronchus in the anterior upper lobe of the right lung on chest computed tomography (CT) (Fig. 1), bronchoscopy was planned with the preliminary diagnoses of lung cancer and tuberculosis, but the patient refused. The results from three samples of sputum acid-resistant bacteria (ARB) were negative, and there were no growths in mycobacteria cultures. Six months later, he was admitted to the emergency department with the complaint of massive hemoptysis (approximately 200 cc/day). The pulmonary CT angiography revealed a cavitary lesion, which progressed when compared to the previous examination, invading the right main bronchus, carina, and vena cava superior (Fig. 2). Tranexamic acid treatment was initiated, and the patient was hospitalized in the intensive care unit. Bronchial artery embolization was performed by the interventional radiology department (Fig. 3). Following the embolization procedure, the hemoptysis significantly decreased in the follow-ups. In the flexible bronchoscopy performed for diagnostic purposes, it was observed that the carina was pushed to the left, and there was damage to the right main bronchus with an invasive appearance (Fig. 4). A biopsy was not performed due to the risk of bleeding, and lavage was performed. ARB analysis was negative in the lavage sample, there was no growth in the mycobacterial culture, and no malignant cells were determined in the cytology. The patient was diagnosed with right main bronchus rupture and was considered inoperable since the mass invaded the vena cava superior, proximal right main bronchus, and carina. The patient died one month later due to respiratory failure.

Fig. 1

Chest computed tomography (CT) indicates an 8 × 7 cm cavitary lesion obliterating the bronchus in the anterior upper lobe of the right lung

Fig. 2

Pulmonary CT angiography reveals a progressive cavitary lesion invading the right main bronchus, carina, and inferior vena cava

Fig. 3

a In the angiogram performed from the right costo-bronchial artery, an appearance compatible with anarchic vascularity in the localization that fits around the cavitary lesion. b After embolization with polyvinyl alcohol (PVA) polymer, it is observed that the anarchic vascularity is lost, and the flow is stagnated

Fig. 4

In flexible bronchoscopy, the carina is pushed to the left and has an invasive appearance and damage to the right main bronchus is observed

Discussion and conclusion

Tracheobronchial injuries (TBI) are rarely observed, and their frequency remains unclear since approximately 80% of the patients die before hospital admission [3, 4]. Most TBIs are iatrogenic or traumatic [5, 6]. It is infrequent for the tumor to rupture the bronchus secondary to direct bronchial invasion. Cases secondary to mediastinal teratoma and germ cell tumor have been reported in the literature, and no rupture due to direct lung cancer has been determined [7,8,9]. In our case, bronchial rupture developed secondary to the mass in the lung without any trauma or iatrogenic cause, but a pathological diagnosis could not be made since no biopsy was performed.

The risk of bronchial rupture increases in intubation with a double-lumen endotracheal tube, frequently used in major thoracic surgery operations [5]. Tracheobronchial injury can also develop due to reasons such as requiring more endobronchial tube manipulation than open thoracotomy during thoracoscopy, collapsed lungs due to carbon dioxide inflation, excessive torsion in the airways, and delayed diagnosis because the procedure is performed in a dark room [5]. Yüceyar et al. reported that only one case of tracheobronchial laceration developed in 900 double-lumen tube intubations [6]. Regarding gender, it has been reported that it most frequently develops in females [10]. The most common site of rupture is the left main bronchus, probably due to the anesthetists’ intubation of the left main bronchus independent of the thoracotomy site and the distal narrowing of the left main bronchus [11]. However, in our case, the bronchial rupture was observed in the right main bronchus because the mass was also on the right.

As a result of bronchial rupture, mediastinal and subcutaneous emphysema (87%), pneumothorax (17-70%), atelectasis, mediastinitis, sepsis, and mortal course may occur [5, 6, 12]. Although the most common symptoms are chest pain, shortness of breath, cough, and fever, hemoptysis may also develop [8, 13]. In our case, massive hemoptysis emerged, and bleeding could only be stopped by bronchial artery embolization.

The significance of computed tomography (CT) in diagnosing TBI is that it can reveal mediastinal emphysema, mediastinal hematoma, and related major vessel injuries that cannot be detected with chest radiography. In the presence of TBI suspicion, even if the CT is normal, the diagnosis should be achieved by performing flexible or rigid bronchoscopy [14]. Bronchoscopic findings include rupture of the bronchial wall, blood in the airway, and collapsed airway with the inability to see and access the distal part of the injury site [15]. In our case, the diagnosis was made with CT and flexible bronchoscopy, which was performed afterward.

Clinical, radiological, and endoscopic findings are determinative in TBI treatment decisions. Conservative treatment is preferred for patients whose laceration is small (less than approximately 2 cm) and suitable for adequate cuff position, or for lacerations that do not involve the entire thickness of the tracheobronchial wall, and for patients who are in poor general condition and at very high surgical risk [16]. In patients other than these, the treatment is surgical, if possible, as soon as the diagnosis is made. The surgical approach can be cervical or posterolateral thoracotomy, depending on the location of the injury [15]. While minor tears and lacerations can be primarily repaired, complete or partial transections require debridement of infected and devitalized tissue, cutting the edges of the injured airway, and end-to-end anastomosis [3, 15]. The literature has also reported that successful outcomes were obtained with minimally invasive robotic-assisted sleeve surgery in a patient who presented with traumatic left main bronchus rupture [17]. If there is extensive bronchial damage, concomitant pulmonary vascular damage, or irreversible lung parenchymal damage, lung resection may be required to effectively control the injury [12]. Gabor et al. reported that when 29 of 31 patients with iatrogenic or traumatic tracheobronchial rupture were treated surgically, and two were treated conservatively, four postoperatively died due to sepsis unrelated to TBI, while the other patients recovered [18]. Conservative treatment includes intubation with the cuff placed distal to the tear, chest tube drainage if necessary, and antibiotic therapy [18]. There are also cases where extracorporeal membrane oxygenation (ECMO) was used in cases of traumatic bronchial rupture [19]. High ventilation pressures should be avoided. High mortality rates in conservatively treated cases can be explained by the worsening general condition of these patients [18].

The reported case was considered inoperable since the mass invaded the superior vena cava, proximal right main bronchus, and carina, and only palliative care was recommended. When there is a delay in diagnosing and treating TBI, airway stenosis or complete bronchial obstruction may develop because the injured bronchus is filled with fibro-granulation tissue and organized hematoma. The case also died 1 month after the diagnosis of bronchial rupture due to respiratory failure.

When the diagnosis and treatment of malignancy are delayed, it should be kept in mind that the patient may be deprived of available treatment options.